The definitional characteristics of CEBs (Sect. 1.3) portray two primary sites of action, the heart and vascular smooth muscle. The acute pharmacologic profile of each CEB reflects actions at both sites. In addition, CEBs can be expected to have other effects related to inhibition of excitation-contraction coupling (e.g. nonvascular smooth muscle) or excitation-secretion coupling. The acute response to CEBs will hemodynamically represent a complex expression of direct (e.g. vasodilator and cardiac) and indirect [e.g. reflex sympathetic activation 565) or inhibition of aldosterone release 566)] effects.
KeywordsHistamine Epinephrine Thrombin Taurine Lanthanum
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