Abstract
The principle examples of the “first generation” of CEBs are verapamil, nifedipine and diltiazem. These three compounds are the reference standards against which new (and many older) compounds are compared. Each is a potent, and to varying degrees a selective CEB and, importantly, each has a distinct chemical structure. The differences in chemical structure give rise to differences in physical or chemical properties, distribution and metabolism, tissue binding characteristics and net biological effects. It is therefore not surprising that the therapeutic efficacy or tolerance of these agents may also be quite different (Sect. 4–5).
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© 1988 Springer-Verlag Berlin Heidelberg
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Smith, R.D., Wolf, P.S., Regan, J.R., Jolly, S.R. (1988). Current Calcium Entry Blocker. In: The Emergence of Drugs which Block Calcium Entry. Progress in Clinical Biochemistry and Medicine, vol 6. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-73228-7_3
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DOI: https://doi.org/10.1007/978-3-642-73228-7_3
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-73230-0
Online ISBN: 978-3-642-73228-7
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