The Neuromuscular Junction

  • M. E. Kriebel
Part of the Handbook of Experimental Pharmacology book series (HEP, volume 86)

Abstract

Physiological studies on the neuromuscular junction (NMJ) are usually concerned with either postsynaptic receptor and channel mechanisms (Chap. 9) or with presynaptic characteristics of transmitter release (Chap. 1). The present chapter will discuss the quantal basis of transmitter release at the NMJ, emphasizing the multiplicity of classes of quanta observed and their pharmacological differences. Quanta are detected as miniature end-plate potentials (mEPPs) which may be divided into at least three main classes: skew-mEPPs, bell-mEPPs, and giant-mEPPs.

Keywords

Fatigue Magnesium Depression Attenuation Acetylcholine 

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© Springer-Verlag Berlin Heidelberg 1988

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  • M. E. Kriebel

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