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The Cholinergic Synapse pp 465–477Cite as

Cholinergic False Transmitters

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Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 86))

Abstract

A false transmitter may be defined as an analogue of an endogenous chemical neurotransmitter which is incorporated into the releasable pool of transmitters and released on stimulation in the same Ca2+-dependent manner as the endogenous transmitter (Kopin 1968). Since in general the agonist action of the false transmitter will differ from that of the endogenous transmitter — normally its pharmacological potency will be lower — the presence of the false transmitter may have significant pharmacological consequences: partial blockade of transmission may ensue. This may result from the displacement of the endogenous transmitter from its storage sites by a less potent false transmitter, but competition for postsynaptic receptors may also be important.

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References

  • Ágoston DV, Kosh JW, Lisziewicz J, Whittaker VP (1985) Separation of recycling and reserve synaptic vesicles from the cholinergic nerve terminals of the myenteric plexus of guinea pig ileum. J Neurochem 45:398–406

    Article  PubMed  Google Scholar 

  • Ágoston DV, Dowe GHC, Fiedler W, Giompres PR, Roed IS, Walker JH, Whittaker VP, Yamaguchi T (1986) The use of synaptic vesicle proteoglycan as a stable marker in kinetic studies of vesicle recycling. J Neurochem 47:1580–1592

    Article  Google Scholar 

  • Barker LA, Mittag TW (1975) Comparative studies of substrates and inhibitors of choline transport and choline acetyltransferase. J Pharmacol 192:86–94

    CAS  Google Scholar 

  • Berry JF, Whittaker VP (1959) The acyl-group specificity of choline acetylase. Biochem J 73:447–458

    PubMed  CAS  Google Scholar 

  • Boksa P, Collier B (1980 a) Acetylation of homocholine by rat brain: subcellular distribution of acetylhomocholine and studies on the ability of homocholine to serve as substrate for choline acetyltransferase in situ and in vitro. J Neurochem 34:1470–1482

    Article  PubMed  CAS  Google Scholar 

  • Boksa P, Collier B (1980 b) N-ethyl analogues of choline as precursors to cholinergic false transmitters. J Neurochem 34:1099–1104

    Article  Google Scholar 

  • Boksa P, Collier B (1980 c) Spontaneous and evoked release of acetylcholine and a cholinergic false transmitter from brain slices: comparison to true and false transmitter in subcellular stores. Neuroscience 5:1517–1532

    Article  PubMed  CAS  Google Scholar 

  • Chiou CY (1974) Studies on action mechanism of a possible false cholinergic transmitter (2-hydroxyethyl methyldiethylammonium). Life Sci 14:1721–1733

    Article  PubMed  CAS  Google Scholar 

  • Collier B, Welner SA (1986) Synthesis, storage and release of choline analogue esters. In: Hanin I (ed) Dynamics of cholinergic function. Plenum, New York, pp 1161–1168

    Google Scholar 

  • Collier B, Barker LA, Mittag TV (1976) The release of acetylated choline analogues by a sympathetic ganglion. Mol Pharmacol 12:340–344

    PubMed  CAS  Google Scholar 

  • Collier B, Lovat S, Ilson D, Barker LA, Mittag TW (1977) The uptake, metabolism and release of homocholine: studies with rat brain synaptosomes and cat superior cervical ganglion. J Neurochem 28:331–339

    Article  PubMed  CAS  Google Scholar 

  • Collier B, Boksa P, Lovat S (1979) Cholinergic false transmitters. Prog Brain Res 49:107–121

    Article  PubMed  CAS  Google Scholar 

  • Colquhoun D, Large WA, Rang HP (1977) An analysis of the action of a false transmitter at the neuromuscular junction. J Physiol (Lond) 266:361–395

    CAS  Google Scholar 

  • Fonnum F (1969) Radiochemical microassays for the determination of choline acetyltransferase and acetylcholinesterase activities. Biochem J 115:465–472

    PubMed  CAS  Google Scholar 

  • Giompres PE, Zimmermann H, Whittaker VP (1981 a) Purification of small dense vesicles from stimulated Torpedo electric tissue by glass bead column chromatography. Neuroscience 6:765–774

    Article  PubMed  CAS  Google Scholar 

  • Giompres PE, Zimmermann H, Whittaker VP (1981 b) Changes in the biochemical and biophysical parameters of cholinergic synaptic vesicles on transmitter release and during a subsequent period of rest. Neuroscience 6:775–785

    Article  PubMed  CAS  Google Scholar 

  • Ilson D, Collier B (1975) Triethylcholine as a precursor to a cholinergic false transmitter. Nature 254:618–620

    Article  PubMed  CAS  Google Scholar 

  • Ilson D, Collier B, Boksa P (1977) Acetyltriethylcholine: a cholinergic false transmitter in cat superior cervical ganglion and rat cerebral cortex. J Neurochem 28:371–381

    Article  PubMed  CAS  Google Scholar 

  • Kilbinger H (1977) Formation and release of acetyl-pyrrolidinecholine (N-methyl-N-acetoxyethylpyrrolidinium) as a false cholinergic transmitter in the myenteric plexus of the guinea-pig small intestine. Naunyn Schmiedebergs Arch Pharmacol 296:153–158

    Article  PubMed  CAS  Google Scholar 

  • Kopin IJ (1968) False adrenergic transmitters. Annu Rev Pharmacol Toxicol 8:377–394

    CAS  Google Scholar 

  • Kosh JW, Whittaker VP (1985) Is propionylcholine present in or synthesized by electric organ? J Neurochem 45:1148–1153

    Article  PubMed  CAS  Google Scholar 

  • Large WA, Rang HP (1978 a) Factors affecting the rate of incorporation of a false transmitter into mammalian motor nerve terminals. J Physiol (Lond) 285:1–24

    CAS  Google Scholar 

  • Large WA, Rang HP (1978 b) Variability of transmitter quanta released during incorporation of a false transmitter into cholinergic nerve terminals. J Physiol (Lond) 285:25–34

    CAS  Google Scholar 

  • Luqmani YA, Richardson PJ (1982) Homocholine and short-chain N-alkyl choline analogues as substrates for Torpedo choline acetyltransferase. J Neurochem 38:368–374

    Article  PubMed  CAS  Google Scholar 

  • Luqmani YA, Whittaker VP (1981) A vesicular site of origin for the release of a false transmitter at the Torpedo synapse. In: Pepeu G, Ladinsky H (eds) Cholinergic mechanisms: phylogenic aspects, central and peripheral synapses and clinical significance. Plenum, New York, pp 47–58

    Google Scholar 

  • Luqmani YA, Sudlow G, Whittaker VP (1980) Homocholine and acetylhomocholine: false transmitters in the cholinergic electromotor system of Torpedo. Neuroscience 5:153–160

    Article  PubMed  CAS  Google Scholar 

  • Newton MW, Jenden DJ (1986) False transmitters as presynaptic probes for cholinergic mechanisms and function. Trends Pharmacol Sci 7:316–320

    Article  CAS  Google Scholar 

  • O’Regan S (1982) The synthesis, storage and release of propionylcholine by the electric organ of Torpedo marmorata. J Neurochem 39:764–772

    Article  PubMed  Google Scholar 

  • O’Regan S (1983) Uptake of acetate and propionate by isolated nerve endings from the electric organ of Torpedo marmorata and their incorporation into choline esters. J Neurochem 41:1596–1601

    Article  PubMed  Google Scholar 

  • O’Regan S (1984) Evaluation of acetate uptake and its relative conversion to acetylcholine in Torpedo electric organ synaptosomes under different ionic and metabolic conditions. Neurochem Int 6:339–346

    Article  PubMed  Google Scholar 

  • Roed, IS (1980) Uptake of false transmitter precursors into synaptosomes derived from a purely cholinergic source. Hoppe-Seyler’s Z Physiol Chem 361:1331

    Google Scholar 

  • Roed IS (1986) Anwendung von integrierter Gaschromatographie-Massenspektrometrie zur Untersuchung der Transmitterkompartimente in rein cholinergen Synapsen von Torpedo marmorata. Dissertation, Göttingen

    Google Scholar 

  • Schwarzenfeld I von (1978) The uptake of acetyl-pyrrolidinecholine — a false cholinergic transmitter — into mammalian cerebral cortical synaptic vesicles. In: Jenden DJ (ed) Cholinergic mechanisms and psychopharmacology. Plenum, New York, pp 657–672

    Google Scholar 

  • Schwarzenfeld I von (1979) Origin of transmitters released by electrical stimulation from a small, metabolically very active vesicular pool of cholinergic synapses in guinea-pig cerebral cortex. Neuroscience 4:477–493

    Article  Google Scholar 

  • Schwarzenfeld I von, Whittaker VP (1977) The pharmacological properties of the cholinergic false transmitter N-2-acetoxyethyl-N-methylpyrrolidinium and its precursor, N-2-hydroxyethyl-N-methylpyrrolidinium. Br J Pharmacol 59:69–74

    Google Scholar 

  • Schwarzenfeld I von, Sudlow G, Whittaker VP (1979) Vesicular storage and release of cholinergic false transmitters. Prog Brain Res 49:163–174

    Article  Google Scholar 

  • Sheridan MN, Whittaker VP, Israël M (1966) The subcellular fractionation of the electric organ of Torpedo. Z Zellforsch 74:291–307

    Article  CAS  Google Scholar 

  • Smith AD (1972) Cellular control of the uptake, storage and release of noradrenaline in sympathetic nerves. Biochem Soc Symp 36:103–131

    PubMed  CAS  Google Scholar 

  • Suszkiw JB, Zimmermann H, Whittaker VP (1978) Vesicular storage and release of acetylcholine in Torpedo electroplaque synapses. J Neurochem 30:1269–1280

    Article  PubMed  CAS  Google Scholar 

  • Welner SA, Collier B (1984) Uptake, metabolism, and releasability of ethyl analogues of homocholine by rat brain. J Neurochem 43:1143–1151

    Article  PubMed  CAS  Google Scholar 

  • Welner SA, Collier B (1985) Accumulation, acétylation and releasability of diethylhomo-choline from a sympathetic ganglion. J Neurochem 45:210–218

    Article  PubMed  CAS  Google Scholar 

  • Whittaker VP (1963) Identification of acetylcholine and related esters of biological origin. In: Koelle GB (ed) Cholinesterases and anticholinesterase agents. Springer, Berlin Göttingen Heidelberg, pp 1–39 (Handbook of experimental pharmacology, vol 15)

    Google Scholar 

  • Whittaker VP (1973) Choline esters other than acetylcholine. In: Michaelson MJ (ed) Int enc pharmacol therap sect 85 comparative pharmacology, vol 1. Pergamon, Oxford, pp 229–240

    Google Scholar 

  • Whittaker VP, Luqmani YA (1980) False transmitters in the cholinergic system: implications for the vesicle theory of transmitter storage and release. Gen Pharmacol 11:7–14

    Article  PubMed  CAS  Google Scholar 

  • Whittaker VP, Michaelson IA, Kirkland RJA (1964) The separation of synaptic vesicles from nerve ending particles (‘synaptosomes’). Biochem J 90:293–303

    PubMed  CAS  Google Scholar 

  • Zimmermann H, Denston CR (1977 a) Recycling of synaptic vesicles in the cholinergic synapses of the Torpedo electric organ during induced transmitter release. Neuroscience 2:695–714

    Article  Google Scholar 

  • Zimmermann H, Denston CR (1977 b) Separation of synaptic vesicles of different functional states from the cholinergic synapses of the Torpedo electric organ. Neuroscience 2:715–730

    Article  PubMed  CAS  Google Scholar 

  • Zimmermann H, Dowdall MJ (1977) Vesicular storage and release of a false cholinergic transmitter (acetylpyrrolcholine) in the Torpedo electric organ. Neuroscience 2:731–739

    Article  PubMed  CAS  Google Scholar 

  • Zimmermann H, Whittaker VP (1977) Morphological and biochemical heterogeneity of cholinergic synaptic vesicles. Nature 267:633–635

    Article  PubMed  CAS  Google Scholar 

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Authors
  1. V. P. Whittaker
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Editors and Affiliations

  1. Arbeitsgruppe Neurochemie, Max-Planck-Institut für biophysikalische Chemie, Postfach 2841, D-3400, Göttingen, Germany

    Victor P. Whittaker

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© 1988 Springer-Verlag Berlin Heidelberg

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Whittaker, V.P. (1988). Cholinergic False Transmitters. In: Whittaker, V.P. (eds) The Cholinergic Synapse. Handbook of Experimental Pharmacology, vol 86. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-73220-1_17

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  • DOI: https://doi.org/10.1007/978-3-642-73220-1_17

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-73222-5

  • Online ISBN: 978-3-642-73220-1

  • eBook Packages: Springer Book Archive

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