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Muscarinic Acetylcholine Receptors

  • Chapter
Book cover The Cholinergic Synapse

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 86))

Abstract

The central and peripheral actions of the endogenous neurotransmitter acetylcholine (ACh) are exerted at two main types of receptor, present in both the central and peripheral nervous system of all mammals. Their definition and pharmacological classification dates back to the work of Sir Henry Dale (1914), who demonstrated that certain actions of ACh on smooth muscle can be mimicked by muscarine while other actions of ACh on, for example, striated muscle can be mimicked by nicotine. The acetylcholine receptors at which muscarine is an agonist are termed muscarinic acetylcholine receptors (mAChRs). Dale also pointed out that the muscarinic actions of ACh can be blocked by atropine. Up to now the use of muscarine as agonist and of atropine as antagonist have provided the best definition of a muscarinic action in all contexts, physiological, pharmacological and biochemical.

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  1. J. Järv

    Present address: Department of Organic Chemistry, Tartu University, Tartu, Estonian SSR, USSR

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  1. Department of Biochemistry, Arrhenius Laboratory, University of Stockholm, Sweden

    J. Järv

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  1. Arbeitsgruppe Neurochemie, Max-Planck-Institut für biophysikalische Chemie, Postfach 2841, D-3400, Göttingen, Germany

    Victor P. Whittaker

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Järv, J., Bartfai, T. (1988). Muscarinic Acetylcholine Receptors. In: Whittaker, V.P. (eds) The Cholinergic Synapse. Handbook of Experimental Pharmacology, vol 86. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-73220-1_11

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  • DOI: https://doi.org/10.1007/978-3-642-73220-1_11

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