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Antipurines and Purine Metabolism

  • Chapter
The Pharmacology of Lymphocytes

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 85))

Abstract

The study of the involvement of purines in lymphocyte function has been highlighted by two dramatic and unrelated discoveries. The first, the discovery in 1958 that 6-mercaptopurine (6-MP) had marked immunosuppressive properties (Schwartz et al. 1958), was followed by the wide use of its S-substituted analog, azathioprine (Aza), to prevent rejection of kidney transplants (Murray et al. 1967). The second, the discovery by Giblett that deficiencies in either of two enzymes of the purine catabolic pathway, adenosine deaminase (ADA) (Giblett et al. 1972) or purine nucleoside phosphorylase (PNP) (Giblett et al. 1975), were associated with immunodeficiency disease, led to many studies involving purine metabolism in lymphocytes as well as the modulation of lymphocyte function by purines.

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  1. G. Wolberg
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Editors and Affiliations

  1. Research Department, CIBA-GEIGY AG, CH-4002, Basel, Switzerland

    Michael A. Bray Ph. D.

  2. Pharmaceutical Division, Preclinical Research, SANDOZ Ltd., CH-4002, Basel, Switzerland

    John Morley Ph. D., FRC Path.

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© 1988 Springer-Verlag Berlin Heidelberg

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Wolberg, G. (1988). Antipurines and Purine Metabolism. In: Bray, M.A., Morley, J. (eds) The Pharmacology of Lymphocytes. Handbook of Experimental Pharmacology, vol 85. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-73217-1_24

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  • DOI: https://doi.org/10.1007/978-3-642-73217-1_24

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