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Cyclosporins: Immunopharmacologic Properties of Natural Cyclosporins

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The Pharmacology of Lymphocytes

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 85))

Abstract

The fungi Tolypocladium inflatum Gams and Cylindrocarpon lucidum Booth are the producers of a series of cyclic oligopeptides called cyclosporins. To date, about 30 of these natural peptides have been isolated and characterized with respect to their chemical composition and immunopharmacologic properties. All these peptides are structurally related to cyclosporin A, and are composed of 11 amino acids. Usually these peptides differ from cyclosporin A by not more than one amino acid.

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Authors
  1. P. C. Hiestand
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  2. H. U. Gubler
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Editor information

Editors and Affiliations

  1. Research Department, CIBA-GEIGY AG, CH-4002, Basel, Switzerland

    Michael A. Bray Ph. D.

  2. Pharmaceutical Division, Preclinical Research, SANDOZ Ltd., CH-4002, Basel, Switzerland

    John Morley Ph. D., FRC Path.

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© 1988 Springer-Verlag Berlin Heidelberg

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Hiestand, P.C., Gubler, H.U. (1988). Cyclosporins: Immunopharmacologic Properties of Natural Cyclosporins. In: Bray, M.A., Morley, J. (eds) The Pharmacology of Lymphocytes. Handbook of Experimental Pharmacology, vol 85. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-73217-1_22

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  • DOI: https://doi.org/10.1007/978-3-642-73217-1_22

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-73219-5

  • Online ISBN: 978-3-642-73217-1

  • eBook Packages: Springer Book Archive

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