Skip to main content
SpringerLink
Log in

Factors Regulating IgE Synthesis

  • Chapter
The Pharmacology of Lymphocytes

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 85))

  • 122 Accesses

Abstract

IgE antibodies are normally involved in the elimination of parasites, but they are also produced in some individuals against antigens which should normally be eliminated by another class of antibody. Such antigens are called allergens. Structural characteristics of antigens may determine allergenicity to some extent, but dysregulation of the immune response is the major reason for the development of IgE-mediated allergy. Recent studies indicate that the type of antibody produced to a particular antigen is governed by Fc receptor-bearing T cells and class-specific immunoglobulin-binding factors which can suppress, or in some cases enhance, the response of that isotype (Löwy et al. 1983). Of the immunoglobulin-binding factors, those which regulate the initiation of an IgE response have been the best studied and are described in this chapter. Mechanisms involved in maintaining a high level of IgE synthesis long after allergen exposure are more complex, and persisting IgE-secreting cells can be refractory to T cell control (Holt and Turner 1985).

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Becker CG, Dublin T (1977) Activation of factor XII by tobacco glycoprotein. J Exp Med 146: 457–467

    Article  PubMed  CAS  Google Scholar 

  • Berger EG, Buddecke E, Kamerling JP, Kobata A, Paulson JC, Vliegenthart JFG (1982) Structure, biosynthesis and functions of glycoprotein glycans. Experientia 38:1129–1162

    Google Scholar 

  • Brocklehurst WE (1978) Passive cutaneous anaphylaxis. In: Weir DM (ed) Immunochemistry. Blackwell, Oxford, pp 21.1–21.6 (Handbook of experimental immunology, vol 1, 3rd edn)

    Google Scholar 

  • Capron A, Ameisen JC, Joseph M, Auriault C, Tonnel AB, Caen J (1985) New functions for platelets and their pathological implications. Int Arch Allergy Appl Immunol 77: 107–114

    Article  PubMed  CAS  Google Scholar 

  • Chen PP, Nonaka M, O’Hair CH, Cohen PA, Zuraw BL, Katz DH (1984) Human IgE syn-thesis in vitro by pokeweed mitogen-stimulated human lymphoid cells: verification with a reconfirmed a specific radioimmunoassay. J Immunol 133: 1909–1913

    PubMed  CAS  Google Scholar 

  • Deguchi H, Suemura M, Ishizaka A, Ozaki Y, Kishimoto S, Yamamura Y, Kishimoto T (1983) IgE class-specific suppressor T cells and factors in humans. J Immunol 131: 2751–2756

    PubMed  CAS  Google Scholar 

  • De Weck AL, Stadler BM, Knutti-Müller J, Ruff P, Hofstetter H, Ludin C, Heusser C (1985) Factors influencing human IgE synthesis in vitro and in vivo. Int Arch Allergy Appl Immunol 77: 38–44

    Article  PubMed  Google Scholar 

  • Francus T, Siskind GW, Becker CG (1983) Role of antigen structure in the regulation of IgE isotype expression. Proc Natl Acad Sci USA 80: 3430–3434

    Article  PubMed  CAS  Google Scholar 

  • Goldsmith PK (1981) A highly sensitive enzyme linked immunosorbent assay for human immunoglobulin E: comparison of microtiter plates and dishes methodologies. Anal Biochem 117: 53–60

    Article  PubMed  CAS  Google Scholar 

  • Hamaoka T, Newburger PE, Katz DH, Benacerraf B (1974) Hapten-specific IgE antibody responses in mice. III. Establishment of parameters for generation of helper T cell function regulating the primary and secondary response of IgE and IgG B lymphocytes. J Immunol 113: 958–973

    Google Scholar 

  • Hirano T, Kumagai Y, Okumura K, Ovary Z (1983) Regulation of murine IgE production: importance of a not-yet-described T cell for IgE secretion demonstrated in SJA9 mice. Proc Natl Acad Sci USA 80: 3435–3438

    Article  PubMed  CAS  Google Scholar 

  • Hirashima M, Yodoi J, Ishizaka K ( 1980a) Regulatory of IgE-binding factors from rat T lymphocytes. IV. Formation of IgE-binding factors in rats treated with complete Freund’s adjuvant. J Immunol 125: 2154–2160

    PubMed  CAS  Google Scholar 

  • Hirashima M, Yodoi J, Ishizaka K (1980b) Regulatory role of IgE-binding factors from rat T lymphocytes. III. IgE-specific suppressive factor with IgE-binding activity. J Immunol 125: 1442–1448

    PubMed  CAS  Google Scholar 

  • Hirashima M, Yodoi J, Huff TF, Ishizaka K (1981a) Formation of IgE-binding factors by rat T lymphocytes. III. Mechanisms of selective formation of IgE-suppressive factors by treatment with complete Freund’s adjuvant. J Immunol 127: 1810–1816

    PubMed  CAS  Google Scholar 

  • Hirashima M, Yodoi J, Ishizaka K (1981b) Regulatory role of IgE-binding factors from rat T lymphocytes. V. Formation of IgE-potentiating factor by T lymphocytes from rats treated with BORDETELLA PERTUSSIS vaccine. J Immunol 126: 838–842

    PubMed  CAS  Google Scholar 

  • Hirata F, Notsu Y, Iwata M, Parente L, DiRosa M, Flower RJ (1982) Identification of several species of phospholipase inhibitory proteins by radioimmunoassay for lipomodulin. Biochem Biophys Res Commun 109: 223–230

    Article  PubMed  CAS  Google Scholar 

  • Holt PG, Turner KJ (1985) Persistent IgE-secreting cells which are refractory to T-cell control. Int Arch Allergy Appl Immunol 77: 45–46

    Article  PubMed  CAS  Google Scholar 

  • Huff TF, Ishizaka K (1984) Formation of IgE-binding factors by human T-cell hybridomas. Proc Natl Acad Sci USA 81: 1514–1518

    Article  PubMed  CAS  Google Scholar 

  • Ishizaka K (1976) Cellular events in the IgE antibody response. Adv Immunol 23:1–75 Ishizaka K (1984) Regulation of IgE synthesis. Annu Rev Immunol 2: 159–182

    Article  Google Scholar 

  • Ishizaka K, Sandberg K (1981) Formation of IgE-binding factors by human T lymphocytes. J Immunol 126: 1692–1696

    PubMed  CAS  Google Scholar 

  • Ishizaka K, Huff TF, Jardieu P, Moore KW, Martens CL (1985) IgE-binding factors. Selective regulation of the IgE responses by T cell factors. Int Arch Allergy Appl Immunol 77: 13–20

    Google Scholar 

  • Iwata M, Huff TF, Uede T, Munoz JJ, Ishizaka K (1983a) Modulation of the biological activities of IgE-binding factor. II. Physicochemical properties and cell sources of glycosylation-enhancing factor. J Immunol 130: 1802–1808

    Google Scholar 

  • Iwata M, Munoz JJ, Ishizaka K (1983b) Modulation of the biological activities of IgEbinding factor. IV. Identification of glycosylation-enhancing factor as a kallikrein-like enzyme. J Immunol 131: 1954–1960

    Google Scholar 

  • Iwata M, Akasaki M, Ishizaka K (1984a) Modulation of the biologic activities of IgE binding factor. VI. The activation of phospholipase by glycosylation enhancing factor. J Immunol 133: 1505–1512

    Google Scholar 

  • Iwata M, Huff TF, Ishizaka K (1984b) Modulation of the biological activities of IgE-binding factor. V. The role of glycosylation-enhancing factor and glycosylation-inhibiting factor in determining the nature of IgE-binding factors. J Immunol 132: 1286–1293

    Google Scholar 

  • Jardieu P, Uede T, Ishizaka K (1984) IgE-binding factors from mouse T lymphocytes. III. Role of antigen-specific suppressor T cells in the formation of IgE-suppressive factor. J Immunol 133: 3266–3273

    Google Scholar 

  • Jardieu P, Moore K, Martens C, Ishizaka K (1985) Relationship among IgE-binding factors with various molecular weights. J Immunol 135: 2727–2734

    PubMed  CAS  Google Scholar 

  • Katz DH (1982) IgE antibody response in vitro: from rodents to man. Prog Allergy 32: 105–160

    PubMed  CAS  Google Scholar 

  • Katz DH (1985) The IgE antibody system is coordinately regulated by FcR epsilon positive lymphoid cells and IgE-selective soluble factors. Int Arch Allergy Appl Immunol 77: 21–25

    Article  PubMed  CAS  Google Scholar 

  • Katz DH, Bargatze RF, Bogowitz CA, Katz LR (1979) Regulation of IgE antibody production by serum molecules. IV. Complete Freund’s adjuvant induces both enhancing and suppressive activities detectable in the serum of low and high responder mice. J Immunol 122: 2184–2190

    Google Scholar 

  • Katz DH, Bogowitz CA, Katz LR (1984) The IgE antibody system: mature, peripheral B lymphocytes exert regulatory influences on the IgE systems of self-reconstituting, sub-lethally irradiated mice. J Mol Cell Immunol 1: 83–89

    PubMed  CAS  Google Scholar 

  • Kishimoto T (1982) IgE class specific suppressor T cells and regulation of the IgE response. Proc Allergy 32: 265–317

    CAS  Google Scholar 

  • Kishimoto T, Hirai Y, Suemura M, Yamamura Y (1976) Regulation of antibody response in different immunoglobulin classes. I. Selective suppression of anti-DNP IgE antibody response by preadministration of DNP-coupled mycobacterium. J Immunol 117: 396–404

    Google Scholar 

  • Kishimoto T, Hirai Y, Suemura M, Nakanishi K, Yamamura Y (1978) Regulation of antibody response in different immunoglobulin classes. IV. Properties and function of “IgE class-specific” suppressor factor(s) released from DNP-Mycobacterium-primed T cells, J Immunol 121: 2106–2112

    PubMed  CAS  Google Scholar 

  • Kishimoto T, Hirai Y, Nakanishi K, Azuma I, Nagamatsu A, Yamamura Y (1979) Regulation of antibody response in different immunoglobulin classes. VI. Selective suppression of IgE response by administration of antigen-conjugated muramylpeptides. J Immunol 123: 2709–2715

    Google Scholar 

  • Kitamura Y, Go S (1979) Decreased production of mast cells in 51/51d anemic mice. Blood 53: 492–497

    PubMed  CAS  Google Scholar 

  • Kitamura Y, Go S, Hatanaka K (1978) Decrease of mast cells in W/W“ mice and their increase by bone marrow transplantation. Blood 52: 447–452

    PubMed  CAS  Google Scholar 

  • Kuff EL, Mietz JA, Trounstine ML, Moore KW, Martens CL (1986) cDNA clones encoding murine IgE-binding factors represent multiple structural variants of intracisternal A-particle genes. Proc Natl Acad Sci USA 83:6583–6587

    Google Scholar 

  • Leung DYM, Young MC, Geha RS (1985) Secretion of IgE-specific potentiating factors by human Fc R T cell lines. Int Arch Allergy Appl Immunol 77: 232–234

    Article  PubMed  CAS  Google Scholar 

  • Liu FT, Bohn JW, Ferry EL, Yamamoto H, Molinaro CA, Sherman LA, Klinman NR, Katz DH (1980) Monoclonal dinitrophenyl-specific murine IgE antibody: preparation, isolation and characterization. J Immunol 124: 2728–2737

    PubMed  CAS  Google Scholar 

  • Löwy I, Brezin C, Neauport-Sautes C, Theze J, Fridman WH (1983) Isotype regulation of antibody production: T-cell hybrids can be selectively induced to produce IgG1 and IgG2 subclass-specific suppressive immunoglobulin-binding factors. Proc Natl Acad Sci USA 80: 2323–2327

    Article  PubMed  Google Scholar 

  • Marcelletti JF, Katz DH (1984) FcRE+ lymphocytes and regulation of the IgE antibody system. III. Suppressive factor of allergy (SFA) is produced during the in vitro FcRE expression cascade and displays corollary physiologic activity in vivo. J Immunol 133: 2837–2844

    PubMed  CAS  Google Scholar 

  • Martens CL, Huff TF, Jardieu P, Trounstine ML, Coffman RL, Ishizaka K, Moore KW (1985) cDNA clones encoding IgE-binding factors from a rat-mouse T cell hybridoma. Proc Natl Acad Sci USA 82:2460-2464

    Google Scholar 

  • Moore KW, Jardieu P, Mietz JA, Trounstine ML, Kuff EL, Ishizaka K, Martens CL (1986) Rodent IgE-binding factor genes are members of an endogenous retrovirus-like gene family. J Immunol 136: 4283–4290

    PubMed  CAS  Google Scholar 

  • Morley J, Page CP, Sanjar S (1985) Pharmacology of the late response and its relevance to asthma prophylaxis. Int Arch Allergy Appl Immunol 77: 73–78

    Article  PubMed  CAS  Google Scholar 

  • Mosbach-Ozmen L, Lehuen-Renard A, Gaveriaux C, Loor F (1986) Membrane alkaline phosphatase activity: an enzymatic marker of B-cell activation. Ann Inst Pasteur Immunol 137D: 109–125

    Google Scholar 

  • Pfeiffer P, König W, Bohn A (1983) Genetic dependence of IgE antibody production in mice infected with the nematode Nippostrongylus brasiliensis. I. Modulation of the IgE antibody response in vivo by serum factors. Int Arch Allergy Appl Immunol 72: 347–355

    Article  PubMed  CAS  Google Scholar 

  • Revoltella R, Ovary Z (1969) Reaginic antibody production in different mouse strains. Immunology 17: 45–54

    PubMed  CAS  Google Scholar 

  • Sarfati M, Rector E, Sehon AH, Delespesse G (1984a) In vitro synthesis of IgE by human lymphocytes. IV. Suppression of the spontaneous IgE synthesis by IgE-binding factors secreted by tunicamycin-treated RPMI 8866 cells. Immunology 53: 783–790

    PubMed  CAS  Google Scholar 

  • Sarfati M, Rector E, Wong M, Rubio-Trujillo M, Sehon AH, Delespesse G (1984b) In vitro synthesis of IgE by human lymphocytes. II. Enhancement of the spontaneous IgE synthesis by IgE-binding factors secreted by RPMI 8866 lymphoblastoid B cells. Immunology 53: 197–205

    PubMed  CAS  Google Scholar 

  • Saryan JA, Leung DYM, Geha RS (1983) Induction of human IgE synthesis by a factor derived from T cells of patients with hyper-IgE states. J Immunol 130: 242–247

    PubMed  CAS  Google Scholar 

  • Spiegelberg HL (1984) Structure and function of Fc receptors for IgE on lymphocytes, monocytes and macrophages. Adv Immunol 35: 61–88

    Article  PubMed  CAS  Google Scholar 

  • Suemura M, Kishimoto T (1985) Regulation of human IgE response by T cells and their products. Int Arch Allergy Appl Immunol 77: 26–31

    Article  PubMed  CAS  Google Scholar 

  • Suemura M, Yodoi J, Hirashima M, Ishizaka K (1980) Regulatory role of IgE-binding factors from rat T lymphocytes. I. Mechanism of enhancement of IgE response by IgE potentiating factor. J Immunol 125: 148–154

    Google Scholar 

  • Suemura M, Shiho O, Deguchi H, Yamamura Y, Böttcher I, Kishimoto T (1981) Characterization and isolation of IgE class-specific suppressor factor (IgE-TsF). I. The presence of the binding site(s) for IgE and of the H-2 gene products in IgE-TsF. J Immunol 127: 465–471

    PubMed  CAS  Google Scholar 

  • Suemura M, Ishizaka A, Kobatake S, Sugimura K, Maeda K, Nakanishi K, Kishimoto S, Yamamura Y, Kishomoto T (1983) Inhibition of IgE production in B hybridomas by IgE class-specific suppressor factor from T hybridomas. J Immunol 130: 1056–1060

    PubMed  CAS  Google Scholar 

  • Sugimura K, Nakanishi K, Maeda K, Kashiwamura SI, Suemura M, Shiho O, Yamamura Y, Kishimoto T (1982) The involvement of two distinct subsets of T cells for the expression of the IgE class specific suppression: establishment and characterization of PC-specific, T15 idiotype-positive T hybridomas and IgE class-specific, antigen-nonspecific T hybridomas. J Immunol 128: 1637–1644

    PubMed  CAS  Google Scholar 

  • Thompson LF, Spiegelberg HL, Buckley RH (1985) IgE Fc receptor positive T and B lymphocytes in patients with the hyper IgE syndrome. Clin Exp Immunol 59: 77–84

    PubMed  CAS  Google Scholar 

  • Toh H, Ono M, Miyata T (1985) Retroviral gag and DNA endonuclease coding sequences in IgE-binding factor gene. Nature 318: 388–389

    Article  PubMed  CAS  Google Scholar 

  • Tung AS, Chiorazzi N, Katz DH (1978) Regulation of IgE antibody production by serum molecules. I. Serum from complete Freund’s adjuvant-immune donors suppresses irradiation-enhanced IgE production on low responder mouse strains. J Immunol 120: 2050–2059

    Google Scholar 

  • Uede T, Ishizaka K (1982) Formation of IgE-binding factors by rat T lymphocytes. VI. Cellular mechanisms for the formation of IgE-potentiating factor and IgE-suppressive factor by antigenic stimulation of antigen-primed spleen cells. J Immunol 129: 1391–1397

    Google Scholar 

  • Uede T, Ishizaka K (1984) IgE-binding factors from mouse T lymphocytes. II. Strain differences in the nature of IgE-binding factor. J Immunol 133: 359–367

    Google Scholar 

  • Uede T, Sandberg K, Bloom BR, Ishizaka K (1983) IgE-binding factors from mouse T lymphocytes. I. Formation of IgE-binding factors by stimulation with homologous IgE and interferon. J Immunol 130: 649–654

    Google Scholar 

  • Uede T, Huff TF, Ishizaka K (1984) Suppression of IgE synthesis in mouse plasma cells and B cells by rat IgE-suppressive factor. J Immunol 133: 803–808

    PubMed  CAS  Google Scholar 

  • Watanabe N, Kojima S, Ovary Z (1976) Suppression of IgE antibody production in SJL mice. I. Nonspecific suppressor T cells. J Exp Med 143: 833–845

    Google Scholar 

  • Watanabe T, Kimoto M, Maruyama S, Kishimoto T, Yamamura Y (1978) Regulation of antibody response in different antibody classes. V. Establishment of T hybrid cell lines secreting IgE class-specific suppressor factor. J Immunol 121: 2113–2117

    Google Scholar 

  • Ymer S, Young IG (1986) Homology between IgE-binding factor gene and endogenous retroviruses. Nature 323: 186–188

    Article  PubMed  CAS  Google Scholar 

  • Yodoi J, Hirashima M, Ishizaka K (1980) Regulatory role of IgE-binding factors from rat T lymphocytes. II. Glycoprotein nature and source of IgE-potentiating factor. J Immunol 125: 1436–1442

    Google Scholar 

  • Yodoi J, Hirashima M, Bloom BR, Ishizaka K (1981) Formation of IgE-binding factors by rat T lymphocytes. I. Induction of IgE-binding factors by poly I: C and interferon. J Immunol 127: 1579–1585

    Google Scholar 

  • Yodoi J, Hirashima M, Ishizaka K (1982) Regulatory role of IgE-binding factors from rat T lymphocytes. V. The carbohydrate moieties in IgE-potentiating and IgE-suppressive factors. J Immunol 128: 289–295

    Google Scholar 

  • Zuraw BL, Nonaka M, O’Hair CH, Katz DH (1981) Human IgE antibody synthesis in vitro: stimulation of IgE responses by pokeweed mitogen and selective inhibition of such responses by human suppressive factor of allergy ( SFA ). J Immunol 127: 1169–1177

    PubMed  CAS  Google Scholar 

Download references

Authors
  1. C. Gaveriaux
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. T. Payne
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. F. Loor
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Research Department, CIBA-GEIGY AG, CH-4002, Basel, Switzerland

    Michael A. Bray Ph. D.

  2. Pharmaceutical Division, Preclinical Research, SANDOZ Ltd., CH-4002, Basel, Switzerland

    John Morley Ph. D., FRC Path.

Rights and permissions

Reprints and permissions

Copyright information

© 1988 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Gaveriaux, C., Payne, T., Loor, F. (1988). Factors Regulating IgE Synthesis. In: Bray, M.A., Morley, J. (eds) The Pharmacology of Lymphocytes. Handbook of Experimental Pharmacology, vol 85. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-73217-1_11

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-73217-1_11

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-73219-5

  • Online ISBN: 978-3-642-73217-1

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation