Skip to main content
SpringerLink
Log in

Production and Measurement of Interferons

  • Chapter
The Pharmacology of Lymphocytes

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 85))

Abstract

Interferons (IFNs) are a set of protein molecules which can be considered as lymphokines (LKs) in that they are produced by and act upon lymphoid organs and cells. However, one can also regard them as a separate system in view of the fact that some of the IFNs can be produced by and respond to nonlymphoid cells. IFNs are a diverse set of molecules, each of which has unique features. One of the most important properties of the whole IFN family is their ability to induce antiviral activity in target cells. It is this unique ability that led to the discovery of the IFNs nearly three decades ago.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Alkan SS (1985) Epitope analysis of six human IFN-alpha subtypes by monoclonal antibodies. In: Dianzani F, Rossi GB (eds) The interferon system. Raven, New York, p 237 (Serono symposia, vol 24)

    Google Scholar 

  • Alkan SS (1986) Specific targeting of interferons by monoclonal antibodies: Potential for targeting other lymphokines. In: Lymphokines, the new super-drugs? Conference, London, 3–4 March 1986. IBC Technical Services, London

    Google Scholar 

  • Alkan SS, Weideli H-J, Schuerch AR (1983) Monoclonal antibodies against human leucocyte interferons for the definition of subclasses and their affinity purification. Protides Biol Fluids 30:495–498

    Google Scholar 

  • Alkan SS, Miescher-Granger S, Braun DG, Hochkeppel HK (1984) Antiviral and antiproliferative effects of interferons delivered via monoclonal antibodies. J Interferon Res 4:355–363

    Article  PubMed  CAS  Google Scholar 

  • Alkan SS, Hochkeppel HK, Küttel L (1985) Epitope analysis by monoclonal antibodies of five human recombinant interferon subtypes. In: Kirchner H, Schellekens H (eds) The biology of the interferon system 1984. Elsevier, Amsterdam, pp 91–98

    Google Scholar 

  • Allen PT, Giron DJ (1970) A rapid sensitive assay for interferons based on the inhibition of MM virus nucleic acid synthesis. Appl Microbiol 20:317–322

    PubMed  CAS  Google Scholar 

  • Armstrong JA (1971) Semi-micro, dye-binding assay for rabbit interferon. Appl Microbiol 21:723–725

    PubMed  CAS  Google Scholar 

  • Becker S (1985) Effect of interferon-gamma on class-II antigen expression and accessory cell function. Sury Immunol Res 4:135–145

    CAS  Google Scholar 

  • Bocci V (1981) Production and role of interferon in physiological conditions. Biol Rev 56:49–85

    Article  PubMed  CAS  Google Scholar 

  • Borden EC (1984) Interferons and cancer: how the promise is being kept. Interferon 5:43–83 Branca AA, Baglioni C (1981) Evidence that type I and II interferons have different receptors. Nature 294:768–770

    Google Scholar 

  • Cantell K (1979) Why is interferon not in clinical use today? Interferon 1:1–28

    Google Scholar 

  • Cantell K, Tovel DR (1971) Substitution of milk for serum in the production of human leucocyte interferon. Appl Microbiol 22:625–628

    PubMed  CAS  Google Scholar 

  • Clemens MJ, McNurlan MA (1985) Regulation of cell proliferation and differentiation by interferons. Biochem J 226:345–360

    PubMed  CAS  Google Scholar 

  • De Maeyer-Guignard J, De Maeyer E (1985) Immunomodulation by interferons: recent developments. Interferon 1: 6:69–91

    Google Scholar 

  • Derynck R, Remaut E, Saman E, Stanssens P, de Clercq E, Content J, Fiers W (1980) Expression of human fibroblast interferon gene in Escherichia coli. Nature 287:193–197

    Article  PubMed  CAS  Google Scholar 

  • Dijkema R, van der Meide PH, Pouwels PH, Caspers M, Dubbeld M, Schellekens H (1985) Cloning and expression of the chromosomal immune interferon gene of the rat. EMBO J 4:761–767

    PubMed  CAS  Google Scholar 

  • Eshhar Z, Novik D, Gigio O, Marks Z, Friedlander Y, Revel M, Rubinstein M (1983) Monoclonal antibodies to human leukocyte and fibroblast interferon. Protides Biol Fluids 30:491–494

    Google Scholar 

  • Giard DJ, Fleischaker RT (1984) A study showing a high degree of interlaboratory variation in the assay of human interferons. J Biol Stand 12:265–269

    Article  PubMed  CAS  Google Scholar 

  • Goeddel DV, Leung DW, Dull TJ, Gross M, Lawn RM, McCandliss R, Seeberg PH et al. (1981) The structure of eight cloned human leukocyte interferon cDNAs. Nature 290:20–26

    Article  PubMed  CAS  Google Scholar 

  • Gordon J, Minks MA (1981) The interferon renaissance: molecular aspects of induction and action. Microbiol Rev 45:244–266

    PubMed  CAS  Google Scholar 

  • Gray PW, Goeddel DV (1983) Cloning and expression of murine immune interferon cDNA. Proc Natl Acad Sci USA 80:5842–5846

    Article  PubMed  CAS  Google Scholar 

  • Gray PW, Leung DW, Pennica D, Yelverton E, Najarian R, Simenson CC, Derynck R et al. (1982) Expression of human immune interferon cDNA in E. coli and monkey cells. Nature 295:503–508

    Article  PubMed  CAS  Google Scholar 

  • Havel EA, Yip YK, Vilcek J (1977) Characteristics of human lymphoblastoid (Namalwa) interferon. J Gen Virol 38:51–59

    Article  Google Scholar 

  • Ho M, Enders JE (1959) An inhibitor of viral activity appearing in infected cell cultures. Proc Natl Acad Sci USA 45:385–389

    Article  PubMed  CAS  Google Scholar 

  • Hochkeppel HK, Alkan SS (1986) Immunomodulatory actions of interferons. In: Revel M (ed) Clinical aspects of interferon. Nijhoff, Boston, (Developments in molecular virology) (1987)

    Google Scholar 

  • Hochkeppel HK, Menge U, Collins J (1981) Monoclonal antibodies against human fibroblast interferon. Eur J Biochem 118:437–442

    Article  PubMed  CAS  Google Scholar 

  • Hoskins M (1935) A protective action of neurotropic against viscerotropic yellow fever virus in Macacus rhesus. Am J Trop Med Hyg 15:675–680

    Google Scholar 

  • Isaacs A, Lindenmann J (1957) Virus interference I. The interferon. Proc R Soc [B] 147:257–267

    Google Scholar 

  • Just M, Berger R, Ruuskanen O, Lünd M, Linder S (1986) Intranasal interferon alfa-2a treatment of common cold. A preliminary study. J Interferon Res [Suppl 1] 6:32

    Google Scholar 

  • Kirchner H (1984) Interferon gamma. Prog Clin Biochem Med 1:169–203

    Article  CAS  Google Scholar 

  • Kirchner H, Marcucci F (1984) Interferon production by leukocytes. In: Vilcek J, de Maeyer E (eds) Interferon and the immune system. Elsevier, Amsterdam, pp 7–34 (Interferon, vol 2)

    Google Scholar 

  • Kirkwood JM, Ernstoff MS (1984) Interferons in the treatment of human cancer. J Clin Oncol 2:336–352

    PubMed  CAS  Google Scholar 

  • Köhler G, Milstein C (1975) Continuous culture of fused cells secreting antibody of predefined specificity. Nature 256:495–497

    Article  PubMed  Google Scholar 

  • Le J, Chang TW, Lio V, Yip YK, Vilcek J (1985) Monoclonal antibodies as structural probes for oligomeric human interferon-gamma. J Interferon Res 5:445–453

    Article  PubMed  CAS  Google Scholar 

  • Liang CM, Herren S, Sand A, Jost T (1985) Study of antigenic epitope recognized by monoclonal antibodies to recombinant interferon-gamma. Biochem Biophys Res Commun 128:171–178

    Article  PubMed  CAS  Google Scholar 

  • Littman SJ, Devos R, Baglioni C (1985) Binding of unglycosylated and glycosylated human recombinant interferon to cellular receptors. J Interferon Res 5:471–476

    Article  PubMed  CAS  Google Scholar 

  • Mayer U (1980) Structural and biological relationships of low molecular weight interferon inducers. Pharmacol Ther 8:173–192

    Article  CAS  Google Scholar 

  • McNeill TA (1981) Interferon assays. J Immunol Methods 46:121–127

    Article  PubMed  CAS  Google Scholar 

  • Merigan TC (1983) Human interferon as a therapeutic agent-current status. N Engl J Med 308:1530–1531

    Article  PubMed  CAS  Google Scholar 

  • Minks AM, Bevin S, Maroney PA, Baglioni C (1979) Synthesis of 2’S-oligo(A) in extracts of interferon-treated HeLa cells. J Biol Chem 254:5058–5064

    PubMed  CAS  Google Scholar 

  • Mogensen KE, Bandu M-T, Vignaux F, Uze G, Eid P (1984) Receptor mediated pathways for interferon action: in vivo implications. Med Oncol Tumor Pharmacother 1:77–85

    PubMed  CAS  Google Scholar 

  • Nagata S, Mantei N, Weissmann C (1980) The structure of one of the eight or more distinct chromosomal genes for human interferon. Nature 287:401–408

    Article  PubMed  CAS  Google Scholar 

  • Orchansky P, Novick D, Fischer DG, Rubinstein M (1984) Type I and type II interferon receptors. J Interferon Res 4:275–282

    CAS  Google Scholar 

  • Pestka S, Langer JA, Fisher PB, Weinsten IB, Ortaldo J, Herberman RB (1985) The human interferons: from the past and into the future. In: Ford RJ, Maizel AL (eds) Mediators in cell growth and differentiation. Raven, New York, pp 261–281

    Google Scholar 

  • Quesada JR, Reuben J, Manning JT, Hersh EM, Gutterman JU (1984) Alpha interferon for induction of remission in hairy cell leukemia. N Engl J Med 310:15–18

    Article  PubMed  CAS  Google Scholar 

  • Revel M (1979) Molecular mechanisms involved in antiviral effects of interferons. Interferon 1:101–163

    CAS  Google Scholar 

  • Rubinstein M, Rubinstein S, Familletti PC, Miller RS, Waldman AA, Pestka S (1979) Human leukocyte interferon: production, purification to homogeneity and initial characterization. Proc Natl Acad Sci USA 76:640–644

    Article  PubMed  CAS  Google Scholar 

  • Rubinstein S, Familetti PC, Pestka S et al. (1981) Convenient assay for interferons. J Virol 37:755–758

    PubMed  CAS  Google Scholar 

  • Secher DS (1981) Immunoradiometric assay of human leukocyte interferon using monoclonal antibody. Nature 290:501–503

    Article  PubMed  CAS  Google Scholar 

  • Secher DV, Burke DC (1980) A monoclonal antibody for large scale purification of human leukocyte interferon. Nature 285:446–450

    Article  PubMed  CAS  Google Scholar 

  • Sedmak JJ, Siebenlist R, Grossberg SE (1985) Human IFN antiviral activity correlates with immunological reactivity in a double-monoclonal antibody radiometric assay. J Interferon Res 5:397–402

    Article  PubMed  CAS  Google Scholar 

  • Shaw GD, Boll W, Taira H, Mantei N, Lengyel P, Weissmann C (1983) Structure and expression of cloned murine IFN genes. Nucleic Acids Res 11:555–573

    Article  PubMed  CAS  Google Scholar 

  • Spitalny GL, Havel EA (1984) Monoclonal antibody to murine gamma interferon inhibits lymphokine-induced antiviral and macrophage tumoricidal activity. J Exp Med 159:1560–1565

    Article  PubMed  CAS  Google Scholar 

  • Staehelin T, Durrer B, Schmidt J, Takacs B, Stocker J, Miggiano V, Stöhle C et al. (1981) Purification and characterization of recombinant human leukocyte interferon (IFNrA) with monoclonal antibodies. J Biol Chem 256:9750–9754

    PubMed  CAS  Google Scholar 

  • Stewart W II (1979) The interferon system. Springer, Vienna New York

    Google Scholar 

  • Taniguchi T, Mantai N, Schwarzstein M, Nagata S, Maramatsu M, Weissmann C (1980a) Human leukocyte and fibroblast interferons are structurally related. Nature 285:547–549

    Article  CAS  Google Scholar 

  • Taniguchi T, Ohno S, Fujii-Kuriyama Y, Muramatsu M (1980b) The nucleotide sequence of human fibroblast interferon cDNA. Gene 10:11–15

    Article  CAS  Google Scholar 

  • Tavernier J, Fiers W (1984) The presence of homologous regions between interferon sequences. Carlsberg Res Common 49:359–364

    Article  CAS  Google Scholar 

  • Towbin H, Gordon J (1984) Immunoblotting and dot immunobinding — current status and outlook. J Immunol Methods 72:313–340

    Article  PubMed  CAS  Google Scholar 

  • Von Gabain A, Ohlsson M, Lindström E, Lundström M, Lundgren E (1986) Polymorphism and gene duplication in the human IFNa and ß gene family. In: Jörnvall H (ed) Molecular evolution of life. Chemica Stripta, vol 26B. Cambridge University Press, Cambridge, pp 357–362

    Google Scholar 

  • Wagner RR (1961) Biological studies of interferon. Suppression of cellular infection with eastern equine encephalomyelitis virus. Virology 13:323–337

    Article  PubMed  CAS  Google Scholar 

  • Yip YK, Roy H, Pang L, Urban C, Vilcek J (1981) Partial purification and characterization of human (immune) interferon. Proc Natl Acad Sci USA 78:1601–1605

    Article  PubMed  CAS  Google Scholar 

  • Zoon KC, Arnheiter H (1984) Studies of the interferon receptors. Pharmacol Ther 24:259–278

    Article  PubMed  CAS  Google Scholar 

Download references

Authors
  1. S. S. Alkan
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Research Department, CIBA-GEIGY AG, CH-4002, Basel, Switzerland

    Michael A. Bray Ph. D.

  2. Pharmaceutical Division, Preclinical Research, SANDOZ Ltd., CH-4002, Basel, Switzerland

    John Morley Ph. D., FRC Path.

Rights and permissions

Reprints and permissions

Copyright information

© 1988 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Alkan, S.S. (1988). Production and Measurement of Interferons. In: Bray, M.A., Morley, J. (eds) The Pharmacology of Lymphocytes. Handbook of Experimental Pharmacology, vol 85. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-73217-1_10

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-73217-1_10

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-73219-5

  • Online ISBN: 978-3-642-73217-1

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation