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Molecular Heterogeneity of Pathogenic Herpes Viruses

  • Conference paper
Book cover Molecular Basis of Viral and Microbial Pathogenesis

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Abstract

Herpes viruses are a large group of enveloped DNA containing animal viruses. More than 80 members of the group have been identified in various vertebrates. All herpes viruses appear identical in electron microscopy. A nucleocapsid with 162 capsomers is surrounded by an irregularly shaped membrane that is derived from the inner nuclear membrane of infected cells. It is common to all herpes viruses that, subsequent to primary infection, they persist in the host organism for life. Persisting herpes viruses can be reactivated, resulting in secondary disease. Herpes viruses are usually divided into three subgroups, based on biological criteria, such as pathogenic properties, organ tropism, and oncogenicity. Alpha-herpes viruses, including Herpes simplex virus (HSV) type 1 and type 2, and varizella-zoster virus (VZV) naturally persist in neural tissues. Human cytomegalovirus (HCMV) is a prototype of beta-herpes viruses. Gamma-herpes viruses are able to persist in lymphoid tissues, and some members have been shown to induce lymphoproliferative diseases. Epstein-Barr Virus (EBV) is a prototype of the gamma-1 subgroup. Two T-cell-transforming herpes viruses of non-human primates Herpes virus (H.) saimiri and H. ateles, are members of the gamma-2-subgroup.

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Author information

Authors and Affiliations

  1. Institut für Klinische und Molekulare Virologie der Universität, Erlangen-Nürnberg, Loschgestr. 7, D-8520, Erlangen, Germany

    B. Fleckenstein

Authors
  1. M. Mach
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  2. H. H. Niller
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  3. B. Fleckenstein
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Editor information

Editors and Affiliations

  1. Institut für Virologie der Universität, Frankfurter Straße 107, 6300, Gießen, Germany

    Rudolf Rott

  2. Institut für Genetik und Mikrobiologie der Universität, Röntgenring 11, 8700, Würzburg, Germany

    Werner Goebel

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© 1987 Springer-Verlag Berlin Heidelberg

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Mach, M., Niller, H.H., Fleckenstein, B. (1987). Molecular Heterogeneity of Pathogenic Herpes Viruses. In: Rott, R., Goebel, W. (eds) Molecular Basis of Viral and Microbial Pathogenesis. Colloquium der Gesellschaft für Biologische Chemie 9.–11. April 1987 in Mosbach/Baden, vol 38. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-73214-0_5

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  • DOI: https://doi.org/10.1007/978-3-642-73214-0_5

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-73216-4

  • Online ISBN: 978-3-642-73214-0

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