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Iron as a Signal in Bacterial Infections

  • Conference paper
Molecular Basis of Viral and Microbial Pathogenesis

Abstract

Insight as to how iron contributes to the pathogenicity of bacteria involves understanding the iron metabolism of the host and of the bacteria. The human host overcomes the extreme insolubility of Fe3+ at pH 7 by binding iron to carrier proteins, in the serum to transferring in secretory fluids to lactoferrin, and within cells to ferritin and hemoglobin. The serum concentration of free iron which is not bound to carrier proteins is only 10-18 M, which stands in sharp contrast to the iron concentration of 10-6 M required for bacterial growth.

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Author information

Authors and Affiliations

  1. Mikrobiologie II, Universität, D-7400, Tübingen, Germany

    V. Braun, E. Fischer & K. Hantke

  2. Immuno AG, Vienna, Austria

    H. Rotering

Authors
  1. V. Braun
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  2. E. Fischer
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  3. K. Hantke
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  4. H. Rotering
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Editor information

Editors and Affiliations

  1. Institut für Virologie der Universität, Frankfurter Straße 107, 6300, Gießen, Germany

    Rudolf Rott

  2. Institut für Genetik und Mikrobiologie der Universität, Röntgenring 11, 8700, Würzburg, Germany

    Werner Goebel

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© 1987 Springer-Verlag Berlin Heidelberg

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Braun, V., Fischer, E., Hantke, K., Rotering, H. (1987). Iron as a Signal in Bacterial Infections. In: Rott, R., Goebel, W. (eds) Molecular Basis of Viral and Microbial Pathogenesis. Colloquium der Gesellschaft für Biologische Chemie 9.–11. April 1987 in Mosbach/Baden, vol 38. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-73214-0_17

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  • DOI: https://doi.org/10.1007/978-3-642-73214-0_17

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-73216-4

  • Online ISBN: 978-3-642-73214-0

  • eBook Packages: Springer Book Archive

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