Long-Term Potentiation of Inhibitory Responses in the Dentate Gyrus
Repeated epileptogenic stimulation (kindling) of the perforant path or the dentate gyrus results in a long-lasting potentiation of 2 components of inhibition as measured from field responses using a double pulse technique. This potentiation of inhibitory responses does not accompany normal LTP of the excitatory input, but preliminary experiments indicate that it may be induced by non-epileptogenic stimulation applied directly to the hilar region. The mechanism underlying this effect appears to be an increase in the number of GABA and benzodiazepine receptors.
KeywordsDentate Gyrus Epileptiform Discharge Paired Pulse Perforant Path Synaptic Potentiation
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