Modulation of Spike Repolarization in Hippocampal Neurones by Tumor-Promoting Phorbol Esters

  • J. F. Storm
Conference paper


Tumor-promoting pborbol esters (TPEs) are known to enhance synaptic transmitter release. This effect is likely to involve protein kinase C (PKC), which is directly activated by TPEs [3]. In the hippocampus, TPEs induce synaptic enhancement which resembles, and occludes, long-term potentiation (LTP) [8], and LTP has been correlated with translocation of PKC [1]. In Aplysia neurones, another protein kinase (PKA) mediates synaptic enhancement which underlies certain forms of learning [5]. The proposed mechanism in Aplysia is inhibition of a K current, leading to a broadening of the presynaptic action potential, increased Ca influx, and enhanced transmitter release [5]. I am investigating the possibility that a similar mechanism may contribute to synaptic plasticity in the hippocampus.


Synaptic Plasticity Hippocampal Neurone Transmitter Release Voltage Clamp Voltage Clamp Experiment 
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  1. 1.
    Akers, R.F., Lovinger, D.M., Colley, P.A., Linden, D.J. and Routtenberg, A., Science, 231 (1986) 587–589.PubMedCrossRefGoogle Scholar
  2. 2.
    Baraban, J.M., Snyder, S.H., and Alger, B.E., Proc.Natl.Acad.Sci. USA, 82 (1985) 2538–2542.PubMedCrossRefGoogle Scholar
  3. 3.
    Castagna, M., Takai, Y., Kaibuchi, K., Sano, K, Kikkawa, U. and Nishizuka, Y., J. biol. Chem. 257 (1982) 7847–7851.PubMedGoogle Scholar
  4. 4.
    Gustafsson, B., Galvan, M., Grafe, P. and Wigström, H.A., Nature, 299 (1982) 252–254.PubMedCrossRefGoogle Scholar
  5. 5.
    Klein, M., Shapiro, E. and Kandel, E.R., J. exp, Biol., 89 (1980) 117–157.Google Scholar
  6. 6.
    Lancaster, B. and Adams, P.R., J. Neurophysiol., 55 (1986) 1268–1282.PubMedGoogle Scholar
  7. 7.
    Madison, D.V., Malenka, R.C. and Nicoll, R.A., Nature, 321 (1986) 695–697.PubMedCrossRefGoogle Scholar
  8. 8.
    Malenka, R.C., Madison, D.V. and Nicoll, R.A., Nature, 321 (1986) 175–177.PubMedCrossRefGoogle Scholar
  9. 9.
    Storm, J. F., J. Physiol. 385 (1987) 733–759.PubMedGoogle Scholar
  10. 10.
    Storm, J.F., Neurosci. letters 75 (1987) 71–74.CrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1988

Authors and Affiliations

  • J. F. Storm
    • 1
  1. 1.Department of Neurobiology and BehaviorState University of New York at Stony BrookStony BrookUSA

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