Modulation of Spike Repolarization in Hippocampal Neurones by Tumor-Promoting Phorbol Esters

  • J. F. Storm
Conference paper

Abstract

Tumor-promoting pborbol esters (TPEs) are known to enhance synaptic transmitter release. This effect is likely to involve protein kinase C (PKC), which is directly activated by TPEs [3]. In the hippocampus, TPEs induce synaptic enhancement which resembles, and occludes, long-term potentiation (LTP) [8], and LTP has been correlated with translocation of PKC [1]. In Aplysia neurones, another protein kinase (PKA) mediates synaptic enhancement which underlies certain forms of learning [5]. The proposed mechanism in Aplysia is inhibition of a K current, leading to a broadening of the presynaptic action potential, increased Ca influx, and enhanced transmitter release [5]. I am investigating the possibility that a similar mechanism may contribute to synaptic plasticity in the hippocampus.

Keywords

Haas Phorbol Aminopyridine Tetraethylammonium 

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Copyright information

© Springer-Verlag Berlin Heidelberg 1988

Authors and Affiliations

  • J. F. Storm
    • 1
  1. 1.Department of Neurobiology and BehaviorState University of New York at Stony BrookStony BrookUSA

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