Effects of Phorbol Esters on Membrane Currents and Synaptic Efficacy in the Hippocampus

  • D. V. Madison
  • R. C. Malenka
  • R. A. Nicoll
Conference paper

Abstract

Application of phorbol esters to hippocampal slices has been shown to enhance synaptic transmission in a way that mimics long term potentiation. These compounds also have effects on a voltage-dependent chloride current that could possibly account for some aspects of this potentiating action.

Keywords

Haas Phorbol 

References

  1. 1.
    Nelson, R.B. and Routtenberg, A. (1985). Experimental Neurology 89, 213–224.PubMedCrossRefGoogle Scholar
  2. 2.
    Akers, R.F. and Routtenberg, A. (1985). Brain Research 334, 147–151.PubMedCrossRefGoogle Scholar
  3. 3.
    Malenka, R.C., Madison, D.V. and Nicoll, R.A. (1987). Nature 321, 175–177.CrossRefGoogle Scholar
  4. 4.
    Malenka, R.C., Ayoub, G.S. and Nicoll, R.A. (1987). Brain Research 403, 198–203.PubMedCrossRefGoogle Scholar
  5. 5.
    Malenka, R.C., Madison, D.V., Andrade, R. and Nicoll, R.A. (1986). Journal of Neuroscience 6, 475–480.PubMedGoogle Scholar
  6. 6.
    Madison, D.V., Malenka, R.C. and Nicoll, R.A. (1987). Nature 321, 695–697.CrossRefGoogle Scholar
  7. 7.
    Baraban, J.M., Snyder, S.H. and Alger, B.E. (1985). Proceedings of the National Academy of Sciences, USA 82, 2538–2542.CrossRefGoogle Scholar
  8. 8.
    Newberry, N.R. and Nicoll, R.A. (1984). Journal of Physiology 348, 239–254.PubMedGoogle Scholar
  9. 9.
    Andersen, P., Sundberg, S.H., Sveen, E., Swann, J.W. and Wigstrom, H. (1980). Journal of Physiology 302, 463–482.PubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1988

Authors and Affiliations

  • D. V. Madison
    • 1
  • R. C. Malenka
    • 1
  • R. A. Nicoll
    • 1
  1. 1.Departments of Pharmacology and PhysiologyUniversity of CaliforniaSan FranciscoUSA

Personalised recommendations