Effects of Phorbol Esters on Membrane Currents and Synaptic Efficacy in the Hippocampus

  • D. V. Madison
  • R. C. Malenka
  • R. A. Nicoll
Conference paper


Application of phorbol esters to hippocampal slices has been shown to enhance synaptic transmission in a way that mimics long term potentiation. These compounds also have effects on a voltage-dependent chloride current that could possibly account for some aspects of this potentiating action.


Hippocampal Slice Phorbol Ester Membrane Current Tetanic Stimulation Synaptic Potential 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1988

Authors and Affiliations

  • D. V. Madison
    • 1
  • R. C. Malenka
    • 1
  • R. A. Nicoll
    • 1
  1. 1.Departments of Pharmacology and PhysiologyUniversity of CaliforniaSan FranciscoUSA

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