Abstract
Long-term potentiation (LTP), a lasting increase in synaptic efficacy seen following high-frequency stimulation, has been extensively studied as a mnemonic model. However, a major conceptual difficulty in relating LTP to an endogenous mechanism for memory formation is that the parameters commonly used for its induction are well beyond the normal physiological firing range of hippocampal neurons: usually 50–400 stimuli, delivered at frequencies of 100–400 Hz, are employed (Teyler and Discenna, 1984). While hippocampal pyramidal cells are known to discharge in “complex-spikes”, consisting of several action potentials at frequencies greater that 100 Hz, groups of 3 or 4 action potentials are most commonly seen (Suzuki and Smith, 1985); continuous high frequency discharge is only observed under experimentally-induced or pathological conditions. We considered the possibility that the threshold for the induction of LTP might be reduced if the pattern of stimulation more accurately reflected normal neuronal firing.
Primed burst potentiation combines two prominent aspects of hippocampal physiology, complex-spike discharge and theta rhythm, to produce lasting increases in evoked responses recorded in area CA1. This effect is seen in both the in vitro slice preparation and in the intact hippocampus of unanesthetized rats.
Chapter PDF
References
Rose, G.M., Dunwiddie, T.V.: Induction of hippocampal long-term potentiation using physiologically patterned stimulation. Neurosci. Lett. 69, 244–248 (1986)
Suzuki, S.S., Smith, G.K.: Burst characteristics of hippocampal complex spike cells in the awake rat. Exp. Neurol. 89, 90–95 (1985)
Teyler, T.J., Discenna, P.: Long-term potentiation as a candidate mnemonic device. Brain Res. Rev. 7, 15–28 (1984)
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1988 Springer-Verlag Berlin Heidelberg
About this paper
Cite this paper
Rose, G.M., Diamond, D.M., Pang, K., Dunwiddie, T.V. (1988). Primed Burst Potentiation: Lasting Synaptic Plasticity Invoked by Physiologically Patterned Stimulation. In: Haas, H.L., Buzsàki, G. (eds) Synaptic Plasticity in the Hippocampus. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-73202-7_28
Download citation
DOI: https://doi.org/10.1007/978-3-642-73202-7_28
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-73204-1
Online ISBN: 978-3-642-73202-7
eBook Packages: Springer Book Archive