Potentiation of Synaptic Transmission by Phorbol Esters is Accompanied by a Reduction of Physiological Adenosine Action

  • P. Schubert
Conference paper


Removal of the physiological adenosine action by theophylline markedly increased the efficiency of synaptic transmission as determined by measuring the evoked neuronal calcium fluxes in a rat hippocampal slice. The theophylline effect was inhibited by 1 uM phorbol-12,13-dibutyrate and also following generation of LTP.


Synaptic Transmission Long Term Potentiation Phorbol Ester Transmitter Release EPSP Amplitude 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1988

Authors and Affiliations

  • P. Schubert
    • 1
  1. 1.Department of NeuromorphologyMax-Planck Institute for PsychiatryMartinsriedFederal Republic of Germany

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