Potentiation of Synaptic Transmission by Phorbol Esters is Accompanied by a Reduction of Physiological Adenosine Action
Removal of the physiological adenosine action by theophylline markedly increased the efficiency of synaptic transmission as determined by measuring the evoked neuronal calcium fluxes in a rat hippocampal slice. The theophylline effect was inhibited by 1 uM phorbol-12,13-dibutyrate and also following generation of LTP.
KeywordsSynaptic Transmission Long Term Potentiation Phorbol Ester Transmitter Release EPSP Amplitude
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