Involvement of Serotonin in Hippocampal Plasticity

  • M. Segal
  • G. Richter


Serotonin (5-hydroxytryptamine, 5-HT) containing fibers originate in the brainstem raphe nuclei and innervate extensively the hippocampus. This innervation is reported to modulate hippocampal reactivity to afferent stimulation in the freely moving rat (Winson 1980) and to affect the expression of long term potentiation of responses to perforant path stimulation (Bliss et al 1983). More recently serotonin has been implicated in the generation of rhythmic hippocampal activity and in “learning” and “memory” (Vanderwolf 1987).


Perforant Path Term Potentiation Serotonin Neuron Raphe Neuron Hippocampal Plasticity 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1988

Authors and Affiliations

  • M. Segal
    • 1
  • G. Richter
    • 1
  1. 1.Center for NeurosciencesThe Weizmann Institute of ScienceRehovotIsrael

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