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Involvement of Serotonin in Hippocampal Plasticity

  • M. Segal
  • G. Richter

Abstract

Serotonin (5-hydroxytryptamine, 5-HT) containing fibers originate in the brainstem raphe nuclei and innervate extensively the hippocampus. This innervation is reported to modulate hippocampal reactivity to afferent stimulation in the freely moving rat (Winson 1980) and to affect the expression of long term potentiation of responses to perforant path stimulation (Bliss et al 1983). More recently serotonin has been implicated in the generation of rhythmic hippocampal activity and in “learning” and “memory” (Vanderwolf 1987).

Keywords

Perforant Path Term Potentiation Serotonin Neuron Raphe Neuron Hippocampal Plasticity 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

  1. Bliss, T.V.P., Goddard, G.V. and Riives, M. Reduction of long term potentiation in the dentate gyrus of the rat following selective depletion of monoamines. J. Physiol. 1983. 334: 475–491.PubMedGoogle Scholar
  2. Vanderwolf, C.H. Near-total loss of ‘learning’ and ‘memory’ as a result of caribined cholinergic and serotonergic blockade in the rat. Behav. Brain Res. 1987. 23: 43–45.PubMedCrossRefGoogle Scholar
  3. Winscai, J. Influence of raphe nuclei on neuronal transmission frcm perforant pathway through dentate gyrus. J. Neurophysiol. 1980. 44: 937–950.Google Scholar
  4. Segal, M. The action of serotonin in the hippocampal slice preparation. J. Physiol. 1980. 33: 423–439.Google Scholar
  5. Segal, M. and Azmitia, E.C. Fetal raphe neurons grafted into the hippocampus develop normal adult physiological properties. Brain Res. 1986. 364: 162–166.PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1988

Authors and Affiliations

  • M. Segal
    • 1
  • G. Richter
    • 1
  1. 1.Center for NeurosciencesThe Weizmann Institute of ScienceRehovotIsrael

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