Myocardial Cell Death and the Possible Role of Sarcolemmal Phospholipids (Based on Morphological Observations)

  • J. A. Post
  • T. J. C. Ruigrok
  • J. M. J. Lamers
  • P. D. Verdouw
  • A. J. Verkleij
Conference paper
Part of the NATO ASI Series book series (volume 16)


This article gives an overview of a series of articles (Post et al., 1985a,b; 1987; Verkleij and Post, 1987), which led to a new hypothesis concerning myocardial cell death and which explains the observed morphological events in the context of current knowledge of the molecular organization of biological membranes. Myocardial cell death secondary to several pathological conditions is accompanied by a calcium overload of the myocardial cell (Alto and Dhalla, 1979; Katz and Reuter, 1979) and seems to be triggered by this overload. Two of the most studied systems for myocardial failure are the calcium-paradox and the ischemia-reperfusion model.


Erythrocyte Ghost Left Ventricular Free Wall Left Circumflex Coronary Artery Calcium Paradox Myocardial Cell Death 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1988

Authors and Affiliations

  • J. A. Post
    • 1
  • T. J. C. Ruigrok
    • 1
    • 2
  • J. M. J. Lamers
    • 1
    • 3
  • P. D. Verdouw
    • 1
    • 4
  • A. J. Verkleij
    • 1
    • 5
  1. 1.Institute of Molecular Biology and BiotechnologyState University UtrechtUtrechtThe Netherlands
  2. 2.Department of Cardiology, University HospitalInteruniversity Cardiology InstituteUtrechtThe Netherlands
  3. 3.Department of BiochemistryErasmus University RotterdamRotterdamThe Netherlands
  4. 4.ThoraxcenterErasmus University RotterdamRotterdamThe Netherlands
  5. 5.Molecular Cell BiologyState University UtrechtUtrechtThe Netherlands

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