Skip to main content
SpringerLink
Log in

Myocardial Cell Death and the Possible Role of Sarcolemmal Phospholipids (Based on Morphological Observations)

  • Conference paper
Membrane Biogenesis

Part of the book series: NATO ASI Series ((ASIH,volume 16))

  • 73 Accesses

Abstract

This article gives an overview of a series of articles (Post et al., 1985a,b; 1987; Verkleij and Post, 1987), which led to a new hypothesis concerning myocardial cell death and which explains the observed morphological events in the context of current knowledge of the molecular organization of biological membranes. Myocardial cell death secondary to several pathological conditions is accompanied by a calcium overload of the myocardial cell (Alto and Dhalla, 1979; Katz and Reuter, 1979) and seems to be triggered by this overload. Two of the most studied systems for myocardial failure are the calcium-paradox and the ischemia-reperfusion model.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Alto LE, Dhalla NS (1979) Myocardial cation contents during induction of the calcium paradox. Am J Physiol 237: H713–H719

    PubMed  CAS  Google Scholar 

  • Ashraf M, Halverson CA (1977) Structural changes in the freeze-fractured sarcolemma of ischemic myocardium. Am J Pathol 88: 583–594

    PubMed  CAS  Google Scholar 

  • Bailey IA, Radda GK, Seymour AL, Williams SR (1982) Effects of insulin on myocardial metabolism and acidosis in normoxia and ischemia. Biochim Biophys Acta 720: 17–29

    Article  PubMed  CAS  Google Scholar 

  • Borgers M, Piper HM (1986) Calcium shifts in anoxic cardiac myocytes. A cytochemical study. J Mol Cell Cardiol 18: 439–448

    Article  PubMed  CAS  Google Scholar 

  • Cullis PR, de Kruijff B, Hope MJ, Verkleij AJ, Nayar R, Farren SB, Tilcock C, Madden TD, Bally MB (1983) Structural properties of lipids and their functional roles in biological membranes. In: Alia RC (ed) Membrane fluidity in biology. Concept of membrane structure. Academic Press New York vol I 39

    Google Scholar 

  • De Kruijff B, Cullis PR, Verkleij AJ, Hope MJ, van Echteid CJA, Taraschi TF, van Hoogevest P, Killian JA, Rietveld A, van der Steen ATM (1985) Modulation of lipid polymorphism by 1ipid-protein interactions. In: Watts A, de Pont JJHHM (eds). Progress in protein-1ipid interactions. Elsevier Science Publishers BV Amsterdam 89

    Google Scholar 

  • Elgsaeter A, Shutton D, Branton D (1976) Intramembrane particle aggregation in erythrocyte ghosts. II. The influence on spectrin aggregation. Biochim Biophys Acta 426: 101–122

    Article  PubMed  CAS  Google Scholar 

  • Frank JS (1983) Ca-depletion of the sarcolemma-ultrastructural changes. Eur Heart J 4 (suppl H): 23–27

    PubMed  CAS  Google Scholar 

  • Glauert AM (1974) Fixatives. In: Glauert AM (ed). Practical methods in electron microscopy. Elsevier/North Holland, Amsterdam Vol 3 p 30

    Google Scholar 

  • Hearse DJ, Humphrey SM, Bullock GR (1978) The oxygen paradox and the calcium paradox: two facets of the same problem? J Mol Cell Cardiol 10: 641–668

    Article  PubMed  CAS  Google Scholar 

  • Hope MJ, Cullis PR (1979) The bilayer stability of inner monolayer lipids from the human erythrocyte. FEBS Lett 107: 323–326

    Article  PubMed  CAS  Google Scholar 

  • Jennings RB, Sommer HM, Kaltenbach JP, West JJ (1964) Electrolyte alterations in acute myocardial ischemic injury. Circ. Res. 14: 260–269

    PubMed  CAS  Google Scholar 

  • Jennings RB, Reimer KA, Jones RN, Peyton RB (1983) High energy phosphates, anaerobic glycolysis and irreversibility in ischemia. In: Spitzer JJ (ed). Myocardial ischemia. Plenum New York p 403

    Google Scholar 

  • Kalina M, Pease DC (1977) The preservation of ultrastructure in saturated phosphatidyl cholines by tannic acid in model systems and type II pneumatocytes. J Cell Biol 74: 726–741

    Article  PubMed  CAS  Google Scholar 

  • Katz AM, Reuter H (1979) Cellular calcium and cardiac cell death. Am J Cardiol 44: 188–190

    Article  PubMed  CAS  Google Scholar 

  • Kloner RA, Ganote CE, Whalen DA, Jennings RB (1974) Effect of a transient period of ischemia on myocardial cells. II. Fine structures during the first minutes of reflow. Am J Pathol 74: 399–422

    PubMed  CAS  Google Scholar 

  • Knoll G, Oebel G, Plattner H (1982) A simple sandwich-cryogen-jet procedure with high cooling rates for cryofixation of biological materials in the native state. Protoplasm 111: 161–176

    Article  Google Scholar 

  • Lelkes G, Lelkes G, Szinyei Merse K, Hollan SR (1983) Intensive, reversible aggregation of intramembrane particles in non-hemolyzed human erythrocytes. A freeze-fracture study. Biochim Biophys Acta 732: 48–57

    Article  PubMed  CAS  Google Scholar 

  • Muir AR (1968) A calcium-induced contracture of cardiac muscle cells. J Anat 102: 148–149

    Google Scholar 

  • Nayar R, Schmidt S, Hope MJ and Cullis PR (1982) Structural preferences of phosphatidyl inositol and phosphatidylinositol-phosphatidyleta-nolamine model membranes. Influence of Ca++ and Mg2+. Biochim Biophys Acta 688: 169–176

    Article  PubMed  CAS  Google Scholar 

  • Nayler WG, Elz JS, Perry SE, Dally MJ (1983) The biochemistry of uncontrolled calcium entry. Eur Heart J 4 (Suppl H): 29–41

    PubMed  CAS  Google Scholar 

  • Op den Kamp JAF (1979) Lipid asymmetry in membranes. Ann Rev Biochem 48: 47–71

    Article  PubMed  CAS  Google Scholar 

  • O’Rourke RA, Hanrath P, Henry WN, Hugenholtz PG, Pisa Z, Roelandt J, Tanaka M (1984) Report of the joint international society and federation of cardiology / World Health Organization task force on recommendations for standardization of measurements from M-mode echocardiograms. Circulation 69: 854A–857A

    PubMed  Google Scholar 

  • Post JA, Leunissen-Bijvelt J, Ruigrok TJC, Verkleij AJ (1985a) Ultra-structural changes of sarcolemma and mitochondria in the isolated rabbit heart during ischemia and reperfusion. Biochim Biophys Acta 845: 119–123

    Article  PubMed  CAS  Google Scholar 

  • Post JA, Nievelstein PFEM, Leunissen-Bijvelt J, Verkleij AJ and Ruigrok TJC (1985b) Sarcolemmal disruption during the calcium-paradox. J Mol Cell Cardiol 17: 265–273

    Article  PubMed  CAS  Google Scholar 

  • Post JA, Lamers JMJ, Verdouw PD, Ten Cate FJ, Van der Giessen WJ, Verkleij AJ (1987) Sarcolemmal destabilization and destruction after ischemia and reperfusion and its relation with long-term recovery of regional left ventricular function in pigs. Eur Heart J 8: 423–430

    PubMed  CAS  Google Scholar 

  • Shen AC, Jennings RB (1972) Myocardial calcium and magnesium in acute ischemic injury. Am J Pathol 67: 417–440

    PubMed  CAS  Google Scholar 

  • Verdouw PD, Remme WJ, Hugenholtz PG (1977) Cardiovascular and antiar-rhythmic effects of apridine (AC 1802) during partial occlusion of a coronary artery in the pig. Cardiovasc Res 11: 317–323

    Article  PubMed  CAS  Google Scholar 

  • Verkleij AJ, Zwaal RFA, Roelofsen B, Comfurius P, Kastelyn D and van Deenen LLM (1973) The asymmetric distribution of phospholipids in the human red cell membrane. Biochim Biophys Acta 323: 178–193

    Article  PubMed  CAS  Google Scholar 

  • Verkleij AJ, Ververgaert PHJTH (1978) Freeze-fracture morphology of biological membranes. Biochim Biophys Acta 515: 303–327

    PubMed  CAS  Google Scholar 

  • Verkleij AJ (1984) Lipidic intramembraneous particles. Biochim Biophys Acta 779: 43–63

    PubMed  CAS  Google Scholar 

  • Verkleij AJ, Post JA (1987) Physicochemical properties and organization of lipids in membranes. Its possible role in myocardial injury. Basic Res Cardiol: in press

    Google Scholar 

  • Zimmerman ANE, Hülsmann WC (1966) Paradoxical influence of calcium ions on the permeability of the cell membranes of the isolated rat heart. Nature 211: 646–647

    Article  PubMed  CAS  Google Scholar 

  • Zimmerman ANE, Daems W, Hülsmann WC, Snijder J, Wisse E, Durrer D (1967) Morphological changes of heart muscle caused by successive perfusion with calcium-free and calcium-containing solution (calcium paradox). Cardiovasc Res 1: 201–209

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Institute of Molecular Biology and Biotechnology, State University Utrecht, Padualaan 8, 3584 CH, Utrecht, The Netherlands

    J. A. Post, T. J. C. Ruigrok, J. M. J. Lamers, P. D. Verdouw & A. J. Verkleij

  2. Department of Cardiology, University Hospital, Interuniversity Cardiology Institute, Utrecht, The Netherlands

    T. J. C. Ruigrok

  3. Department of Biochemistry, Erasmus University Rotterdam, Rotterdam, The Netherlands

    J. M. J. Lamers

  4. Thoraxcenter, Erasmus University Rotterdam, Rotterdam, The Netherlands

    P. D. Verdouw

  5. Molecular Cell Biology, State University Utrecht, Utrecht, The Netherlands

    A. J. Verkleij

Authors
  1. J. A. Post
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. T. J. C. Ruigrok
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. J. M. J. Lamers
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. P. D. Verdouw
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. A. J. Verkleij
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Laboratory of Biochemistry, State University of Utrecht, Padualaan 8, P.O. Box 80054, 3508 TB, Utrecht, The Netherlands

    Jos A. F. Op den Kamp

Rights and permissions

Reprints and permissions

Copyright information

© 1988 Springer-Verlag Berlin Heidelberg

About this paper

Cite this paper

Post, J.A., Ruigrok, T.J.C., Lamers, J.M.J., Verdouw, P.D., Verkleij, A.J. (1988). Myocardial Cell Death and the Possible Role of Sarcolemmal Phospholipids (Based on Morphological Observations). In: Op den Kamp, J.A.F. (eds) Membrane Biogenesis. NATO ASI Series, vol 16. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-73184-6_8

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-73184-6_8

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-73186-0

  • Online ISBN: 978-3-642-73184-6

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation