Skip to main content
SpringerLink
Log in

Factors which may Alter the Assembly of Biomembranes so as to Influence their Structure or Function

  • Conference paper
Membrane Biogenesis

Part of the book series: NATO ASI Series ((ASIH,volume 16))

Abstract

We are currently using both simple liposomes and mammalian cells to study factors possibly governing the dynamics of assembly of biomembranes. Some factors we found to be important to the properties of simple liposomes as well as biomembranes are 25-hydroxycholesterol, 25-hydroxycholecalciferol, 26-hydroxycholesterol and the oxidation products of highly unsaturated fatty acids. They effect the permeability of membranes to Ca+ ions and the phospholipid head group composition of biomembranes. Their influence on membranes is concentration dependent. It is, in some cases, dependent on the presence of antioxidants which counteract their influence on biomembranes, the presence of surface active agents and yet unknown factors.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Bauer PJ (1981) Affinity and stoichimetry of calcium binding by arsenazo III. Analyt Biochem 110: 61–72

    Article  PubMed  CAS  Google Scholar 

  • Brasitus TA, Dudeja PK, Eby B, Lau K (1986) Correction by 1,25-dihydroxycholecalciferol of the abnormal fluidity and lipid composition of enterocyte brush border membranes in Vitamin D deprived rats. J Biol Chem 261: 16404–16409

    PubMed  CAS  Google Scholar 

  • Danielsson H (1973) Mechanism of bile acid biosynthesis. In: The Bile Acids, vol. 2. Nair PP and Kritchevsky D (eds), Plenum Press, New York

    Google Scholar 

  • Deamer DW, Bangham AD (1976) Large volume liposomes by an ether vaporization method, Biophys Acta 443: 629–634

    Article  CAS  Google Scholar 

  • Donahue TJ, Cain BD, Kaplan S (1982) Alterations in the phospholipid composition of rhodopseudomonas sphaeroides and other bacteria induced by tris, J of Bacteriology, 152: 595–606

    Google Scholar 

  • Emken EA (1983) Biochemistry of unsaturated fatty acid isomers. J Am Oil Chem Soc 60: 995–1004

    Article  CAS  Google Scholar 

  • Glavind J, Hartmann S (1951) The occurrence of peroxidized lipids in atheromatous human aortas. Experienta 7: 464–474

    CAS  Google Scholar 

  • Hagan RC, Leszczynski DE, Kummerow FA (1984) Comparative plasma lipid response of pullets and laying hens to estradiol and progesterone. Toxicology and Applied Pharmacology 76: 483–489

    Article  PubMed  CAS  Google Scholar 

  • Hallam TJ, Rink TJ (1985) Responses to adenosine diphosphate in human platelets loaded with the fluorescent calcium indicator quin 2. J Physiol 368: 131–146

    PubMed  CAS  Google Scholar 

  • Holmes RP, Kummerow FA (1983) The relationship of adequate and excessive intake of vitamin D to health and disease. J Am Clin Nutr 2: 173–199

    CAS  Google Scholar 

  • Holmes RP, Mahfouz M, Travis BD, Yoss N, Keenan M (1983) The effect of membrane lipid composition on the permeability of membranes to Ca2+, In: Biomembranes and Cell Function. Kummerow FA, Benga G, Holmes RP (eds). New York Acad of Sci, New York Vol. 144 p. 44–56

    Google Scholar 

  • Holmes RP, Kummerow FA (1985) Membrane perturbations in atherosclerosis. In: Membrane Fluditiy in Biology, vol. 3. Aloia RC, Boggs JM, (eds). Academic Press Inc, NY pp. 281–305

    Google Scholar 

  • Holmes RP (1985) The influence of membrane lipids on the permeability of membranes to Ca2+. In: Structure and Properties of cell membranes. Vol. 2. Benga G, (ed). CRC Press Boca Raton, Florida

    Google Scholar 

  • Kamio A, Kummerow FA, Imai H (1977) Degeneration of aortic smooth muscle cells in swine fed excess vitamin Do. Arch Pathol Lab Med 101: 378–381

    PubMed  CAS  Google Scholar 

  • Kou I-Ling (1987) The influence of dietary cholesterol on 26-hydroxy- cholesterol and the effect of 26-hydroxycholesterol on the intracellular free calcium level. Ph.D. thesis. The University of Illinois, Urbana, IL pp. 57–63

    Google Scholar 

  • Kummerow FA (1983) Modification of cell membrane composition by dietary lipids and its implication for atherosclerosis. In: Biomembranes and Cell Function. Kummerow FA, Benga G, Holmes RP (eds). Ann New York Acad Sci New York Vol. 414 p. 29–43

    Google Scholar 

  • Kummerow FA (1987) Nutritional aspects of isomeric fats. In: Lipids in Modern Nutrition. Vol. 13. Horisberger M and Bracco U (eds). Nestle Nutrition, Vevey/Raven Press pp. 213–221

    Google Scholar 

  • Leszczynski DE, Hagan RC, Rowe SE, Kummerow FA (1984) Plasma sex horome and lipid patterns in normal and restricted-ovulator chicken hens. General and Comp Endocrinology 55: 280–288

    Article  CAS  Google Scholar 

  • Leszczynski DE, Pikul J, Kummerow FA (1987) Lipid oxidation in plasma and tissue from estrogenized chicken hens. Biol Med and Metal Biol (in press)

    Google Scholar 

  • Moriarity NJ (1987) The synthesis separation and identification of methyl arachidonate hydroperoxide positional isomers and their effect as components of large unilamellar vesicles on vesicle calcium ion uptake. Ph.D. thesis. The University of Illinois, Urbana, IL pp. 32–58

    Google Scholar 

  • Olson FC, Hunt CA, Szoka FC, Vail WJ, Papahadjopoulos (1979) Preparation of liposomes of defied size distribution by extrusion through poly carbanate membranes. Biochim Biophys Acta 557: 9–23

    Article  PubMed  CAS  Google Scholar 

  • Rasmussen H, Matsumoto T, Fontaine O, Goodman DBP (1982) Role of changes in membrane lipid structure in the action of 1,25-dihydroxyvitamin D3. Fed Proc 41: 72–77

    PubMed  CAS  Google Scholar 

  • Serhan C, Anderson P, Goodman E, Dunham P, Weissmann G (1981) Phosphatidate and oxidized fatty acids on calcium ionophores-studies employing arsenazo III in liposomes. J Biol Chem 256: 2736–2741

    PubMed  CAS  Google Scholar 

  • Sheu S, Sharma VK, Banerjec SP (1984) Measurement of cytoplasmic free calcium concentration in isolated ral ventricular myocytes with quin 2. Circulation Res 55: 830–834

    PubMed  CAS  Google Scholar 

  • Smith TL, Toda T, Kummerow FA (1985) Plasma lipid peroxidation in hyperlipidemic chickens. Atherosclerosis 57: 119–122

    Article  PubMed  CAS  Google Scholar 

  • Smith TL, Kummerow FA (1987) Serum lipid peroxidation and atherosclerosis in restricted ovulator chickens. 4th Int‘l Congress on Oxygen Radicals, Nat’l Bureau of Standards, Univ. Cal. at San Diego, June 30 p. 98

    Google Scholar 

  • Sullivan SG, Stern A (1984) Membrane protein changes induced by test-butyl hydroperoxide in red blood cells. Biochim Biophys Acta 774: 215

    Article  PubMed  CAS  Google Scholar 

  • Summerfield FW, Tappel AL (1976) Determination of maldialdehyde-DNA cross-links by fluorescence and incorporation of tritium. Analyt Biochem 111: 77

    Article  Google Scholar 

  • Taura S, Taura M, Kummerow FA (1978) Human arterio- and atherosclerosis: Identical to that in a 6 and 36 month old swine fed a corn diet free of cholesterol and saturated fat. Artery 4(2): 100–106

    CAS  Google Scholar 

  • Taura S, Taura M, Imai H, Kummerow FA, Tokuyasu K, Cho BHS (1979) Ultrastructure of cardiovascular lesions induced by hypervitaminosis D and its withdrawal. Arterial Wall 4(4): 249–259.

    Google Scholar 

  • Toda T, Leszczynski DE, McGibbon WH, Kummerow FA (1980) Coronary arterial lesions in sexually mature non-layers, layers and roosters. Virchows Arch A Path Anat and Hist 388: 123–125

    Article  CAS  Google Scholar 

  • Tokuyasu K, Imai H, Taura S, Cho S, Kummerow FA (1980) Aortic lesions in nonlaying hens with endogenous hyperlipidemia. Arach Pathol Lab Med 104: 41–45

    CAS  Google Scholar 

  • Tracy R (1987) Louisiana State University Medical School, New Orleans LA personal communication

    Google Scholar 

  • Vincent M, Galley J (1984) Time-resolved fluorescence anisotrophy study of effect of cis double bond on structure of lecithin and cholesterol-lecithin bilayers using n-(9-anthroxyloxy) fatty acids as probes. Biochem 23: 6514–6522

    Article  CAS  Google Scholar 

  • Weissmann C, Anderson P, Serhan C, Samuelsson E, Goodman E (1980) A general method employing arsenazo III in liposomes for study of calcium ionophores. Results with A23187 and prostaglandins. Nat’l Acad Sci USA 77: 1506–1510

    Article  CAS  Google Scholar 

  • Yachnin S, Streuli RA, Gordon LI, Hsu RC (1979) Alternation of peripheral blood cell membrane function and morphology by oxygenated sterol; a membrane insertion hypothesis. In: Current Topics in Hemotology Vol. 2. Alan R. Liss Inc. New York

    Google Scholar 

  • Ylä-Herttuala S, Sumuvuori H, Karkola K, Möttönen M, Nikkari T (1987) Atherosclerosis and biochemical composition of coronary arteries in Finnish men. Atherosclerosis 65: 109–115

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Burnsides Research Laboratory, University of Illinois, 1208 West Pennsylvania Avenue, Urbana, Illinois, 61801, USA

    Fred A. Kummerow

Authors
  1. Fred A. Kummerow
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Laboratory of Biochemistry, State University of Utrecht, Padualaan 8, P.O. Box 80054, 3508 TB, Utrecht, The Netherlands

    Jos A. F. Op den Kamp

Rights and permissions

Reprints and permissions

Copyright information

© 1988 Springer-Verlag Berlin Heidelberg

About this paper

Cite this paper

Kummerow, F.A. (1988). Factors which may Alter the Assembly of Biomembranes so as to Influence their Structure or Function. In: Op den Kamp, J.A.F. (eds) Membrane Biogenesis. NATO ASI Series, vol 16. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-73184-6_7

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-73184-6_7

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-73186-0

  • Online ISBN: 978-3-642-73184-6

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation