Blood-Brain Amino Acid Transport During Development
Protein synthesis in the developing brain is higher than in adult brain (1) while the capillary density is lower (2). It thus seems probable that there is a difference in blood-brain amino acid transport across the blood-brain barrier mainly by three system: one system for large neutral amino acids (the system L), one system for basic amino acids, one system for acidic amino acids (3) and perhaps a fourth system for small neutral amino acids which is referred to as the ASC system (4). The ASC and acidic systems have a small activity and amino acids are mainly transported by the L and basic amino acid systems. The problem is, that if there is a high blood-brain transport of amino acids in young animals, does it come through a high transport of all amino acids or through specific modifications of some transport systems as seen in other tissues (5).
KeywordsAmino Acid Transport Neutral Amino Acid Large Neutral Amino Acid Arterial Concentration Neutral Amino Acid Transport
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