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Neuroendocrine Responses to Tryptophan as an Index of Brain Serotonin Function

  • P. J. Cowen
Part of the NATO ASI Series book series (volume 20)

Abstract

Drugs that increase brain serotonin (5-hydroxytryptamine, 5-HT) function elevate plasma levels of certain anterior pituitary hormones, notably prolactin (PRL), ACTH and growth hormone (GH) (1). Administration to humans of the serotonin precursor L-tryptophan (LTP), reliably elevates plasma PRL concentration (1). The present chapter reviews the evidence that this neuroendocrine response is mediated by increases in brain 5-HT function and also examines whether abnormal PRL responses to LTP are seen in depressed patients.

Keywords

Depressed Patient Growth Hormone Response Neuroendocrine Response Anterior Pituitary Hormone Prolactin Response 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 1988

Authors and Affiliations

  • P. J. Cowen
    • 1
  1. 1.MRC Unit of Clinical Pharmacology and University Department of PsychiatryLittlemore HospitalOxfordEngland

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