Disproportionate Amino Acid Diets and Anorexic Responses in Rats: The Role(s) of Limbic Brain Areas and Noradrenergic and Serotoninergic Systems
The role of protein and amino acids in the control of food intake has long been of interest. As early as 1931, Rose (1) stated that an amino acid deficiency was synonymous with a reduction in food intake. Indeed, along with energy, each of the macronutrients in turn has been considered to have the primary role in hypotheses about the control of feeding behavior. The “Aminostatic” theory has gained few adherents, and it is acknowledged that diets with balanced protein content between approximately 15 and 30 or 35% have little or no effect on feeding. However, reductions in food intake and dietary avoidance are reliably found with diets that: 1, have a protein content outside the 15–35% range, 2, contain an excess of one or more amino acids, 3, are devoid of one or more amino acids, or 4, induce an amino acid imbalance. The food intake depression that occurs with amino acid imbalance will be the focus of the studies to be discussed here.
KeywordsDepression Serotonin Norepinephrine Leucine Monoamine
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