Advertisement

Disproportionate Amino Acid Diets and Anorexic Responses in Rats: The Role(s) of Limbic Brain Areas and Noradrenergic and Serotoninergic Systems

  • D. W. Gietzen
  • Q. R. Rogers
  • P. M. B. Leung
Part of the NATO ASI Series book series (volume 20)

Abstract

The role of protein and amino acids in the control of food intake has long been of interest. As early as 1931, Rose (1) stated that an amino acid deficiency was synonymous with a reduction in food intake. Indeed, along with energy, each of the macronutrients in turn has been considered to have the primary role in hypotheses about the control of feeding behavior. The “Aminostatic” theory has gained few adherents, and it is acknowledged that diets with balanced protein content between approximately 15 and 30 or 35% have little or no effect on feeding. However, reductions in food intake and dietary avoidance are reliably found with diets that: 1, have a protein content outside the 15–35% range, 2, contain an excess of one or more amino acids, 3, are devoid of one or more amino acids, or 4, induce an amino acid imbalance. The food intake depression that occurs with amino acid imbalance will be the focus of the studies to be discussed here.

Keywords

Anterior Cingulate Cortex Locus Ceruleus Limit Amino Acid Amino Acid Pattern Amino Acid Diet 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1).
    ROSE, W. C. (1931). Feeding experiments with mixtures of highly purified amino acids. l. The inadequacy of diets containing 19 amino acids. J. Biol. Chem. 94: 155–165.Google Scholar
  2. 2).
    HARPER, A. E., BENEVENGA, N. J., WOHLHUETER, R. M. (1970). Effects of ingestion of disproportionate amounts of amino acids. Physiol. Rev. 50: 428–558.PubMedGoogle Scholar
  3. 3).
    ROGERS, Q. R., LEUNG, P. M. B. (1977). The control of food intake: When and how are amino acids involved? In: The Chemical Senses and Nutrition ( Kare, M. R., Mailer, O., eds.). Academic Press, New York, pp. 213–249.Google Scholar
  4. 4).
    GIETZEN, D. W., LEUNG, P. M. B., CASTONGUAY, T. W., HARTMAN, W. J., ROGERS, Q. R. (1986). Time course of food intake and plasma and brain amino acid concentrations in rats fed amino acid-imbalanced or -deficient diets. In: Interaction of the Chemical Senses with Nutrition ( Kare, M. R., Brand, J. G, eds.). Academic Press, New York, pp. 415–456.Google Scholar
  5. 5).
    PENG, Y., TEWS, J. K., HARPER, A. E. (1972). Amino acid imbalance, protein intake, and changes in rat brain and plasma amino acids. Am. J. Physiol. 222: 314–321.PubMedGoogle Scholar
  6. 6).
    LEUNG, P. M. B., ROGERS, Q. R. (1969). Food intake: Regulation by plasma amino acid pattern. Life Sci. 8: 1–9.PubMedCrossRefGoogle Scholar
  7. 7).
    LEUNG, P. M. B., ROGERS, Q. R. (1987). The effect of amino acids and protein on dietary choice. In: Umani: A Basic Taste ( Kawamura, Y., Kare, M. R., eds.). Marcell Dekker Inc., New York, pp. 565–610.Google Scholar
  8. 8).
    KRAUSS, P. M., MAYER, J. (1965). Influence of protein and amino acids on food intake in the rat. Am. J. Physiol 209: 479–483.PubMedGoogle Scholar
  9. 9).
    NASSET, E. S., RIDLEY, P. T., SCHENK, E. A. (1967). Hypothalamic lesions related to ingestion of an imbalanced amino acid diet. Am. J. Physiol 213: 645–650.PubMedGoogle Scholar
  10. 10).
    LEUNG, R M. B., ROGERS, Q. R. (1971). Importance of prepyriform cortex in food intake response of rats to amino acids. Am. J. Physiol. 221: 929–935.PubMedGoogle Scholar
  11. 11).
    LEUNG, P. M. B., ROGERS, Q. R. (1970). Effect of amino acid imbalnce and deficiency on food intake of rats with hypothalamic lesions. Nutr. Rep. Internat 1: 1–10.Google Scholar
  12. 12).
    LEUNG, P. M. B., ROGERS, Q. R. (1980). Hyperphagia after ventral tegmental lesions and food intake responses of rats fed disproportionate amounts of dietary amino acids. Physiol. Behay. 25: 457–464.CrossRefGoogle Scholar
  13. 13).
    LEUNG, P. M. B., ROGERS, Q. R. (1971). Effects of pituitary extract on food intake of intact and hypophysectomized rats fed imbalanced amino acid diets. Nutr. Rep. Internat 4: 207–215.Google Scholar
  14. 14).
    GIETZEN, D. W., LEUNG, R M. B., ROGERS, Q. R. (1986). Norepinephrine and amino acids in prepyriform cortex of rats fed imbalanced amino acid diets. Physiol. Behay. 36: 1071–1080.CrossRefGoogle Scholar
  15. 15).
    GREEN, A. R., HEAL, D. J. (1985). The effects of drugs on serotonin-mediated behavioural models. In: Neuropharmacology of Serotonin (Green, A. R., ed.). Oxford Univ. Press, Oxford, pp. 326365.Google Scholar
  16. 16).
    LAKOSKI, J. M., AGHAJANIAN, G. K. (1985). Effects of ketanserin on neuronal responses to serotonin in the prefrontal cortex, lateral geniculate and dorsal raphe nucleus. Neuropharmacology 24: 265–273.PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1988

Authors and Affiliations

  • D. W. Gietzen
    • 1
  • Q. R. Rogers
    • 1
  • P. M. B. Leung
    • 1
  1. 1.Department of Physiological Sciences School of Veterinary MedicineUniversity of CaliforniaDavisUSA

Personalised recommendations