Abstract
Numerous new findings challenge widely accepted views of the microanatomical basis and the chemical complexity of neuroeffector communication in many systems (Burnstock 1976, Dismukes 1979, Schmitt 1984,Vizi 1985, Changeux 1986, Eccles 1986, Hökfelt et al 1986, Iversen 1986). The aim of this mini-review is to discuss five aspects of an emerging new paradigm of sympathetic neurotransmission (Burnstock 1986, Lundberg and Hökfelt 1986, Stjärne 1986a,b, Stjärne and Lundberg 1986), namely its view on (1) the relative roles of the different sympathetic messengers, (2) the factors determining the composition of the ‘transmitter cocktail’ the nerve impulse releases from a varicosity, (3) the intermittent and monoquantal secretory activity of individual varicosities, (4) the heterogeneity of varicosities and the complementary roles of quanta released into the ‘intra-’ or ‘extrajunctional’ biophases, and (5) the conditions determining whether a released messenger will act directly and phasically (in ‘transmitter mode’) or indirectly and tonically (in ‘modulator’ mode).
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Stjärne, L. (1988). The New Paradigm: Sympathetic Neurotransmission by Lateral Interaction Between Single Mixed Quanta Acting in Two Different Biophases. In: Zimmermann, H. (eds) Cellular and Molecular Basis of Synaptic Transmission. NATO ASI Series, vol 21. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-73172-3_24
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