Abstract
Most nerve terminals contain various types of vesicles which differ with regard to their appearance in the electron-microscope and presumably also their molecular properties. Profiles of cholinergic nerve terminals from e.g. motor neurons or parasympathetic fibres contain in addition to the numerous electron-lucent vesicles with a diameter of about 45 nm also few dense-cored vesicles with a diameter of about 80–150 nm. In addition, such nerve terminals may contain coated vesicles.
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Agoston DV, Ballmann M, Coulon JM, Dowe GCH, Whittaker VP (1 985) Isolation of neuropeptide-containing vesicles from the guinea pig ileum. J Neurochem 45: 398–406
Bixby JL, Reichardt LF (1985) The expression and localization of synaptic vesicle antigens at neuromuscular junctions in vitro. J Neurosci 5: 3070–3080
Buckley K, Kelly RB (1985) Identification of a transmembrane glycoprotein for secretory vesicles of neural and endocrine cells. J Cell Biol 100: 1284–1294
DeCamilli P, Harris SM, Huttner WB, Greengard P (1983) Synapsin I (protein I), a nerve termina1 - specific phosphoprotein. II. Its specific association with synaptic vesicles demonstrated by immunocytochemistry in agarose-embedded synaptosomes. J Cell Biol 96: 1355–1373
Kuhn DM, Volknandt W, Stadler H, Zimmermann H (1987) Cholinergic vesicle specific proteoglycan. Stability in isolated vesicles and in synaptosomes during induced transmitter release. J Neurochem, in press
Llinis R, McGuiness TL, Leonard CS, Sugimori M, Greengard P (1985) Intraterminal injection of synapsin I or calcium/ calmodulin-dependent protein kinase II alters neurotransmitter release at the squid giant synapse. Proc Natl Acad Sci USA 82: 3035–3039
Matthew D, Tsavaler L, Reichardt LF (1981) Identification of a synaptic vesicle-specific membrane protein with a wide distribution in neuronal and secretory tissue. J Cell Biol 91: 257–269
Pratt MM (1986) Stable complexes of axoplasmic vesicles and microtubules: protein composition and ATPase activity. J Cell Biol 103: 957–968
Rehm H, Wiedenmann B, Betz H (1986) Molecular characterization of synaptophysin, a major calcium-binding protein of the synaptic vesicle membrane. EMB0 J 5: 535–541
Richardson PJ, Brown SJ (1987) ATP release from affinity-purified rat cholinergic nerve terminals. J Neurochem 48: 622–630
Somogyi P, Hodgson AJ, De Potter RW, Fischer-Colbrie R, Schober M, Winkler H, Chubb IW (1984) Chromogranin immunoreactivity in the central nervous system. Immunochemical characterization, distribution and relationship to catecholamine and enkephalin pathways. Brain Res Rev 8: 192–230
Stadler H, Kiene M-L (1987) Synaptic vesicles in electromoto-neurones. II. Heterogeneity of populations is expressed in uptake properties; exocytosis and insertion of a core proteoglycan into the extracellular matrix. EMBO J 6: 2217–2221
Stelzl H, Grondal EJM, Zimmermann H (1987) Ca2+ dependency and substrate specificity of cholinergic synaptic vesicle ATPase. Neurochem Int 11: 107–111
Volknandt W, Zimmermann H (1986) Acetylcholine, ATP, and proteoglycan are common to synaptic vesicles isolated from the electric organs of electric eel and electric catfish as well as from rat diaphragm. J Neurochem 47: 1449–1462
Volknandt W, Naito S, Ueda T, Zimmermann H (1987a) Synapsin I is associated with cholinergic nerve terminals in the electric organs of Torpedo, Electrophorus, and Malapterurus and copurifies with Torpedo synaptic vesicles. J Neurochem 49: 342–347
Volknandt W, Schober M, Fischer-Colbrie R, Zimmermann H, Winkler H (1987b) Cholinergic nerve terminals in the rat diaphragm are chromogranin A immunoreactive. Neurosci Lett 81: 241–244
Volknandt W, Henkel A, Zimmermann H (1988) Heterogenous distribution of synaptophysin and protein 65 in synaptic vesicles isolated from rat cerebral cortex. Neurochem Int, in press
Walker JH, Kristjansson Gl, Stadler H (1986) Identification of a synaptic vesicle antigen (Mr 86,000) conserved between Torpedo and rat. J Neurochem 46: 875–881
Wiedenmann B, Franke WW, Kuhn C, Moll R, Gould VE (1986) Syn-aptophysin: a marker protein for neuroendocrine cells and neoplasms. Proc Natl Acad Sci USA 83: 3500–3504
Wileman T, Harding C, Stahl P (1985) Receptor-mediated endocytosis. Biochem J 232: 1–14
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© 1988 Springer-Verlag Berlin Heidelberg
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Volknandt, W., Henkel, A., Zimmermann, H. (1988). Synaptic Vesicle Proteins. In: Zimmermann, H. (eds) Cellular and Molecular Basis of Synaptic Transmission. NATO ASI Series, vol 21. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-73172-3_22
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DOI: https://doi.org/10.1007/978-3-642-73172-3_22
Publisher Name: Springer, Berlin, Heidelberg
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