Potassium Channels in Rat Brain Synaptosomes: Pharmacology and Toxicology

  • Mordecai P. Blaustein
  • Dieter K. Bartschat
  • Christina G. Benishin
  • William E. Brown
  • Kathryn A. Colby
  • Bruce K. Krueger
  • Mary J. Schneider
  • Roger G. Sorensen
Part of the NATO ASI Series book series (volume 21)


Potassium channels appear to be the most diverse group of ion channels in biological systems (Hille, 1984; Yellen, 1987). Neuronal K channels play key roles in the control of membrane potential, action potential repolarization, repetitive firing, and higher functions such as learning and memory. However, relatively little is known about the properties of K channels in presynaptic nerve terminals because these channels are difficult to study with traditional electrophysiological methods. This is a significant gap in our knowledge because these nerve terminal K channels may play a critical role in the control of synaptic transmission.


Synaptic Membrane Scorpion Toxin Presynaptic Nerve Terminal Delayed Rectifier Snake Toxin 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1988

Authors and Affiliations

  • Mordecai P. Blaustein
    • 1
  • Dieter K. Bartschat
    • 1
  • Christina G. Benishin
    • 1
  • William E. Brown
    • 2
  • Kathryn A. Colby
    • 1
  • Bruce K. Krueger
    • 1
  • Mary J. Schneider
    • 1
  • Roger G. Sorensen
    • 1
  1. 1.Department of PhysiologyUniversity of Maryland School of MedicineBaltimoreUSA
  2. 2.Department of Biological SciencesCarnegie-Mellon UniversityPittsburghUSA

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