Modulation of Glutamate and Gaba Release by Excitatory Amino Acid Receptor Agonists in Cultured Cerebellar Cells

  • G. Levi
  • V. Gallo
  • C. Giovannini
  • R. Suergiu
Part of the NATO ASI Series book series (volume 19)

Abstract

The major excitatory input to the cerebellar cortex is represented by the mossy fibers, whose terminals form synaptic contacts with the granule cells dendrites (Palay and Chan—Palay 1974). It has been suggested that some of these fiber terminals use glutamate or aspartate as a transmitter (Kaneko et al. 1987). This proposal would be consistent with the presence of excitatory amino acid receptors on cerebellar granule cells, which was demonstrated both biochemically (Wroblewski et al. 1985; Nicoletti et al. 1986) and electrophysiologically (Cull—Candy and Ogden 1985).

Keywords

Sucrose Retina CaCl Tate Inositol 

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Copyright information

© Springer-Verlag Berlin Heidelberg 1988

Authors and Affiliations

  • G. Levi
    • 1
  • V. Gallo
    • 1
  • C. Giovannini
    • 1
  • R. Suergiu
    • 1
  1. 1.Istituto Superiore di SanitàLaboratorio di Fisiopatologia di Organo e di SistemaRomaItaly

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