Modulation of Glutamate and Gaba Release by Excitatory Amino Acid Receptor Agonists in Cultured Cerebellar Cells
The major excitatory input to the cerebellar cortex is represented by the mossy fibers, whose terminals form synaptic contacts with the granule cells dendrites (Palay and Chan—Palay 1974). It has been suggested that some of these fiber terminals use glutamate or aspartate as a transmitter (Kaneko et al. 1987). This proposal would be consistent with the presence of excitatory amino acid receptors on cerebellar granule cells, which was demonstrated both biochemically (Wroblewski et al. 1985; Nicoletti et al. 1986) and electrophysiologically (Cull—Candy and Ogden 1985).
KeywordsKainic Acid Cerebellar Granule Cell Kynurenic Acid Excitatory Amino Acid Receptor Aminooxyacetic Acid
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- Ferkany JW, Coyle JT (1982) Kainic acid selectively stimulates the release of endogenous excitatory acidic amino acids, J Pharmacol Exp Ther 225: 399–406.Google Scholar
- Ferkany JW, Zaczek R, Coyle JT (1982) Kainic acid stimulates excitatory amino acid neurotransmitter release at presynaptic receptors Nature 298: 757–759.Google Scholar
- Gallo V, Giovannini C., Levi G (1988) Expression of excitatory amino acid receptors and neurotransmitter amino acid release in cultured cerebellar neural cells, in Heuter G, ed., “Amino Acid Availability and Brain Function in Health and Disease”, Springer-Verlag, in press.Google Scholar
- Gallo V, Suergiu R, Giovannini C, Levi G (1987b) Glutamate receptor subtypes in cultured cerebellar neurones: modulation of glutamate and GABA release, J Neurochem, in press.Google Scholar
- London ED, Coyle JT (1979) Specific binding of 3H-kainic acid to receptor sites in rat brain, Molec Pharmacol 15, 492–505.Google Scholar
- Palay SL, Chan-Palay V (1974) Cerebellar cortex. Cytology and organization, Springer-Verlag, Berlin.Google Scholar