Modulation of Neuromuscular Transmission in the Locust by Fmrfamide-Like Peptides
The levels of modulatory substances present in the local, hormonal environment of a synapse can clearly affect the efficacy of synaptic transmission between the presynaptic and postsynaptic neurone. Modulatory compounds may arrive at their target sites either as circulating neurohormones or as locally released hormones, but may also be released as cotransmitters from anatomically defined synaptic connections. Many of the chemical effectors present in the nervous system, such as particular peptides or biogenic amines, may function as either neurotransmitters, neuromodulators or neurohormones in different contexts. Thus for any specific chemical effector, its functional role must be studied individually in relation to the particular synaptic system under consideration and, wherever possible, in relation to the effects of uniquely identifiable neurones.
KeywordsBiogenic Amine Pancreatic Polypeptide Neuromuscular Transmission Ventral Nerve Cord Motor Neurone
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