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Neurotransmitters, Ion Channels and Second Messengers in the Hippocampus

  • Conference paper
Modulation of Synaptic Transmission and Plasticity in Nervous Systems

Part of the book series: NATO ASI Series ((ASIH,volume 19))

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Abstract

The mechanisms by which neurotransmitter receptors are coupled to ion channels has been the focus of a great deal of research since the discovery that neurotransmitters can alter neuronal excitability by acting on voltage-dependent, as well as voltage-independent, ion channels. Using the in vitro hippocampal slice preparation we have examined the role of second messenger systems and GTP-binding proteins (G-proteins) in mediating the actions of a variety of neurotransmitters found in the hippocampus. Specifically we have examined the actions of norepinephrine (NE), acetylcholine (ACh), serotonin (5-HT), and baclofen (a GABAB receptor agonist).

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References

  • Andrade R, Malenka RC, Nicoll RA (1986) A G protein couples serotonin and GABAb receptors to the same potassium channels in hippocampus. Science 234:1261–1265

    Article  PubMed  CAS  Google Scholar 

  • Andrade R, Nicoll RA (1987) Pharmacologically distinct actions of serotonin on single pyramidal neurones of the rat hippocampus recorded in vitro. J Physiol, in press

    Google Scholar 

  • Baraban JM, Snyder SH, Alger BE (1985) Protein kinase C regulates ionic conductance in hippocampal pyramidal neurons: electrophysiological effects of phorbol esters. Proc Natl Acad Sci 82:2538–2542

    Article  PubMed  CAS  Google Scholar 

  • Benardo LS, Prince DA (1982) Ionic mechanisms of cholinergic excitation in mammalian hippocampal pyramidal cells. Brain Res 249:333–344

    Article  PubMed  CAS  Google Scholar 

  • Berridge MJ, Irvine RF (1984) Inositol trisphosphate, a novel second messenger in cellular signal transduction. Nature 312:315–321

    Article  PubMed  CAS  Google Scholar 

  • Cole AE, Nicoll RA (1983) Acetylcholine mediates a slow synaptic potential in hippocampal pyramidal cells. Science 221:1299–1301

    Article  PubMed  CAS  Google Scholar 

  • Cole AE, Nicoll RA (1984) Characterization of a slow cholinergic postsynaptic potential recorded in vitro from rat hippocampal pyramidal cells. J Physiol 352:173–188

    PubMed  CAS  Google Scholar 

  • Dutar P, Nicoll RA (1987) A role for phosphatidylinositol (PI) turnover in the muscarinic blockade of the M-current in hippocampal pyramidal cells. Neurosci Abst 13, in press.

    Google Scholar 

  • Fisher SK, Klinger PD and Agranoff BW (1983) Muscarinic agonist binding and phospholipid turnover in brain. J Biol Chem 258:7358–7363

    PubMed  CAS  Google Scholar 

  • Haas HL, Konnerth A (1983) Histamine and noradrenaline decrease calcium-activated potassium conductance in hippocampal pyramidal cells. Nature 302:432–434

    Article  PubMed  CAS  Google Scholar 

  • Halliwell JV and Adams PR (1982) Voltage-clamp analysis of muscarinic excitation in hippocampal neurons. Brain Res 250:71–92

    Article  PubMed  CAS  Google Scholar 

  • Jakobs KH, Bauer S, Watanabe Y (1985) Modulation of adenylate cyclase of human platelets by phorbol esters. Eur J Biochem 151:425–430

    Article  PubMed  CAS  Google Scholar 

  • Katada T, Gilman AG, Watanabe Y, Bauer S, Jakobs KH (1985) Protein kinase C phosphorylates the inhibitory guanine nucleotide-binding regulatory component and apparently suppresses its function in hormonal inhibition of adenylate cyclase. Eur J Biochem 151:431–434

    Article  PubMed  CAS  Google Scholar 

  • Lancaster B, Nicoll RA (1987) Properties of two calcium-activated hyperpolarizations in rat hippocampal neurones. J Physiol 389:187–204

    PubMed  CAS  Google Scholar 

  • Madison DV, Nicoll RA (1982) Noradrenaline blocks accommodation of pyramidal cell discharge in the hippocampus. Nature 299:636–638

    Article  PubMed  CAS  Google Scholar 

  • Madison DV, Nicoli RA (1984) Control of the repetitive discharge of rat CA1 pyramidal neurones in vitro. J Physiol 354:319–331

    PubMed  CAS  Google Scholar 

  • Madison DV, Nicoli RA (1986a) Actions of noradrenaline recorded intracellular in rat hippocampal CA1 pyramidal neurones, in vitro. J Physiol 372:221–244

    PubMed  CAS  Google Scholar 

  • Madison DV, Nicoli RA (1986b) Cyclic adenosine 3‘5’-monophosphate mediates beta-receptor actions of noradrenaline in rat hippocampal pyramidal cells. J Physiol 372:245–259

    PubMed  CAS  Google Scholar 

  • Madison DV, Lancaster B and Nicoli RA (1987) Voltage clamp analysis of cholinergic action in the hippocampus. J. Neurosci. 7:733–741

    PubMed  CAS  Google Scholar 

  • Madison DV, Malenka RC and Nicoli RA (1986) Phorbol esters block a voltage-sensitive chloride current in hippocampal pyramidal cells. Nature 321:695–697

    Article  PubMed  CAS  Google Scholar 

  • Malenka RC, Madison DV, Andrade R, Nicoli RA (1986a) Phorbol esters mimic some cholinergic actions in hippocampal pyramidal neurons. J Neurosci 6:475–480

    PubMed  CAS  Google Scholar 

  • Malenka RC, Madison DV, Nicoli RA (1986b) Potentiation of synaptic transmission in the hippocampus by phorbol esters. Nature 321:175–177

    Article  PubMed  CAS  Google Scholar 

  • Malenka RC, Ayoub GS, Nicoli RA (1987) Phorbol esters enhance transmitter release in rat hippocampal slices. Brain Res 403:198–203

    Article  PubMed  CAS  Google Scholar 

  • Newberry NR, Nicoli RA (1985) Comparison of the action of baclofen with gamma-aminobutyric acid on rat hippocampal pyramidal cells in vitro. J Physiol 360:161–185

    PubMed  CAS  Google Scholar 

  • Nishizuka Y (1984) The role of protein kinase C in cell surface signal transduction and tumor promotion. Nature 308:693–698

    Article  PubMed  CAS  Google Scholar 

  • Rogawski MA, Aghajanian GK (1980) Modulation of lateral geniculate neurone excitability by noradrenaline microiontophoresis or locus coeruleus stimulation. Nature 287:731–734

    Article  PubMed  CAS  Google Scholar 

  • Segal M (1980) The action of serotonin in the rat hippocampal slice preparation. J Physiol 303:423–439

    PubMed  CAS  Google Scholar 

  • Storm JF (1987) Action potential repolarization and a fast afterhyper- polarization in rat hippocampal pyramidal cells. J Physiol 385:733–759

    PubMed  CAS  Google Scholar 

  • Tokimasa T (1985) Intracellular Ca2+-ions inactivate K+-current in bullfrog sympathetic neurons. Brain Res 337:386–391

    Article  PubMed  CAS  Google Scholar 

  • Woodward DJ, Moises HC, Waterhouse BD, Hoffer BJ, Freedman R (1979) Modulatory actions of norepinephrine in the central nervous system. Fed Proc 38:2109–2116

    PubMed  CAS  Google Scholar 

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Author information

Authors and Affiliations

  1. Departments of Pharmacology and Physiology, University of California, San Francisco, California, 94143-0450, USA

    R. C. Malenka, D. V. Madison, P. Dutar, R. Andrade & R. A. Nicoll

Authors
  1. R. C. Malenka
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  2. D. V. Madison
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  3. P. Dutar
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  4. R. Andrade
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  5. R. A. Nicoll
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Editor information

Editors and Affiliations

  1. Institut für Pharmakologie, Universität Freiburg, Hermann-Herder-Str. 5, 7800, Freiburg i. Br., Germany

    Georg Hertting

  2. Institut Für Biologie III, Universität Freiburg, Schänzlestr. 1, 7800, Freiburg i. Br., Germany

    Hanns-Christof Spatz

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© 1988 Springer-Verlag Berlin Heidelberg

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Malenka, R.C., Madison, D.V., Dutar, P., Andrade, R., Nicoll, R.A. (1988). Neurotransmitters, Ion Channels and Second Messengers in the Hippocampus. In: Hertting, G., Spatz, HC. (eds) Modulation of Synaptic Transmission and Plasticity in Nervous Systems. NATO ASI Series, vol 19. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-73160-0_14

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  • DOI: https://doi.org/10.1007/978-3-642-73160-0_14

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-73162-4

  • Online ISBN: 978-3-642-73160-0

  • eBook Packages: Springer Book Archive

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