Neurotransmitters, Ion Channels and Second Messengers in the Hippocampus

  • R. C. Malenka
  • D. V. Madison
  • P. Dutar
  • R. Andrade
  • R. A. Nicoll
Conference paper
Part of the NATO ASI Series book series (volume 19)


The mechanisms by which neurotransmitter receptors are coupled to ion channels has been the focus of a great deal of research since the discovery that neurotransmitters can alter neuronal excitability by acting on voltage-dependent, as well as voltage-independent, ion channels. Using the in vitro hippocampal slice preparation we have examined the role of second messenger systems and GTP-binding proteins (G-proteins) in mediating the actions of a variety of neurotransmitters found in the hippocampus. Specifically we have examined the actions of norepinephrine (NE), acetylcholine (ACh), serotonin (5-HT), and baclofen (a GABAB receptor agonist).


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Copyright information

© Springer-Verlag Berlin Heidelberg 1988

Authors and Affiliations

  • R. C. Malenka
    • 1
  • D. V. Madison
    • 1
  • P. Dutar
    • 1
  • R. Andrade
    • 1
  • R. A. Nicoll
    • 1
  1. 1.Departments of Pharmacology and PhysiologyUniversity of CaliforniaSan FranciscoUSA

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