Neurotransmitters, Ion Channels and Second Messengers in the Hippocampus
The mechanisms by which neurotransmitter receptors are coupled to ion channels has been the focus of a great deal of research since the discovery that neurotransmitters can alter neuronal excitability by acting on voltage-dependent, as well as voltage-independent, ion channels. Using the in vitro hippocampal slice preparation we have examined the role of second messenger systems and GTP-binding proteins (G-proteins) in mediating the actions of a variety of neurotransmitters found in the hippocampus. Specifically we have examined the actions of norepinephrine (NE), acetylcholine (ACh), serotonin (5-HT), and baclofen (a GABAB receptor agonist).
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