In Vivo Cytotoxicity of Metallopurpurins to Bladder Tumors

  • A. R. Morgan
  • G. M. Garbo
  • R. W. Keck
  • S. H. Selman
Conference paper
Part of the NATO ASI Series book series (volume 15)

Abstract

We have recently described the use of purpurins in photodynamic therapy (PDT) of cancer.1 The reported use of metallophthalocyanines as effective dyes in PDT2 encouraged us to study the potential use of metallopurpurins as photosensitizers in PDT.

Keywords

Zinc Chloroform Phthalocyanine Hematoporphyrin Purpurin 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Morgan AR, Garbo GM, Kreimer-Birnbaum M, Keck RW, Chauduri K, Selman SH (1987) Morphological Study of the Combined Effect of Purpurin Derivatives and Light on Transplantable Rat Bladder Tumors. Cancer Res 47: 496–498Google Scholar
  2. 2.
    Spikes JD (1986) Phthalocyanines as Photosensitizers in Biological Systems and for the Photodynamic Therapy of Tumors. Photochem Photobiol 43: 691–700CrossRefGoogle Scholar
  3. 3.
    Klaunig JE, Selman SH, Shulok JR, Schafer PJ, Britton SL, Goldblatt PJ (1985) Morphological Studies on Bladder Tumors Treated With Hematoporphyrin Derivative Photochemotherapy. Am J Pathol 119: 230–243Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1988

Authors and Affiliations

  • A. R. Morgan
    • 1
    • 2
  • G. M. Garbo
    • 1
    • 2
  • R. W. Keck
    • 1
    • 2
    • 3
  • S. H. Selman
    • 1
    • 2
    • 3
  1. 1.Department of ChemistryUniversity of ToledoToledoUSA
  2. 2.Department of Medicinal ChemistryUniversity of ToledoToledoUSA
  3. 3.Medical College of OhioUSA

Personalised recommendations