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Porphyrin-Protein Interaction

  • Conference paper
Photosensitisation

Part of the book series: NATO ASI Series ((ASIH,volume 15))

Abstract

Several proteins are able to bind porphyrins, but because of their function few are interacting specifically. These few proteins are enzymes in the heme biosynthetic pathway and proteins like the so-called Z-protein in the liver. The first enzyme in that pathway that binds a porphyrin-like molecule is uroporphyrinogen synthetase. This enzyme and the enzymes catalyzing the next steps, uroporphyrinogen cosynthetase and uroporphyrinogen decarboxylase are located in the cytoplasm. The last enzymes, coproporphyrinogen oxidase, protoporphyrinogen oxidase and ferrochelatase are located in the mitochondria. Only these last two enzymes are proteins that bind porphyrins. Little is known of the porphyrin binding properties of these enzymes. The Michaelis Menten constants for various porphyrin(ogen)s are summarized in table I.

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Author information

Authors and Affiliations

  1. Department of Medical Biochemistry, Sylvius Laboratories, University of Leiden, P.O.Box 9503, 2300 RA, Leiden, The Netherlands

    T. M. A. R. Dubbelman

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  1. T. M. A. R. Dubbelman
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Editor information

Editors and Affiliations

  1. Laboratoire de Biophysique, INSERM U 201, CNRS UA 481, Rue Buffon, 75005, Paris, France

    Giuliana Moreno

  2. Muséum National d’Histoire Naturelle 61, Rue Buffon, 75005, Paris, France

    Giuliana Moreno

  3. Department of Chemistry and Chemical Engineering, Royal Military College of Canada Kingston, K7K 5LO, Ontario, Canada

    Roy Henry Pottier

  4. Department of Chemistry, Paisley College, PA1 2BE, Paisley, Scottland,UK

    Terence George Truscott

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© 1988 Springer-Verlag Berlin Heidelberg

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Dubbelman, T.M.A.R. (1988). Porphyrin-Protein Interaction. In: Moreno, G., Pottier, R.H., Truscott, T.G. (eds) Photosensitisation. NATO ASI Series, vol 15. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-73151-8_59

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  • DOI: https://doi.org/10.1007/978-3-642-73151-8_59

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-73153-2

  • Online ISBN: 978-3-642-73151-8

  • eBook Packages: Springer Book Archive

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