Hematoporphyrin-Manganese : A Contrast Agent for Tumors in Magnetic Resonance Imaging
Magnetic Resonance Imaging (MRI) is a diagnostic tool of primary importance for the investigation of tumors. Relaxation times of malignant, as compared to normal tissues, determine the image contrast of cancerous tumors. We therefore used MRI for the characterization of tumors and of their evolution during treatment employing photodynamic therapy using porphyrins. This work led to the preparation of a complex of a paramagnetic ion with the porphyrin in order to modify, by dipolar relaxation of water protons, the image constrast in tumors and organs. We decided to use hematoporphyrin-manganese and report the preliminary result obtained by magnetic resonance relaxometry, MRI, and photoacoustic spectroscopy on different mouse organs.
KeywordsCrystallization Toxicity Albumin Manganese Porphyrin
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