Photophysical and Photodynamic Properties of New Photosensitizers

  • P. A. Firey
  • T. W. Jones
  • H.-Y. Chang
  • M. E. Kenney
  • M. A. J. Rodgers
Conference paper
Part of the NATO ASI Series book series (volume 15)

Abstract

Currently, there is much research interest in new photosensitizers with intense far red optical absorptions. Such absorption properties would permit deeper penetration of exciting light into the skin and lower doses of photosensitizer. In our laboratory, we have been working in two areas with regard to these new photosensitizers. First, we are using time-resolved nanosecond flash photolysis to characterize excited states of these new, and also certain older, photosensitizers in vivo. Second, we are measuring the photodynamic cell killing of HeLa cells by two new photosensitizers, bis(tri-n-hexylsiloxy-2,3-naphthalocyanato) silicon (SiNC) (Firey and Rodgers, 1987) and bis(dibutyl-octadecylsiloxy-2,3-naphthalocyanato) silicon (BuSiNC).

Keywords

Zinc Permeability Choline Myeloma Porphyrin 

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Bibliography

  1. Bellnier DA, Dougherty TJ (1972) Membrane lysis in Chinese hamster ovary cells treated with hematoporphyrin derivative plus light. Photochem Photobiol 36: 43–47CrossRefGoogle Scholar
  2. Firey PA, Rodgers MAJ (1987) Photo-properties of a silicon naphthalocya- nine: A potential photosensitizer for photodynamic therapy. Photochem Photobiol 45: 535–538Google Scholar

Copyright information

© Springer- Verlag Berlin Heidelberg 1988

Authors and Affiliations

  • P. A. Firey
    • 1
  • T. W. Jones
    • 1
  • H.-Y. Chang
    • 1
    • 2
  • M. E. Kenney
    • 1
    • 2
  • M. A. J. Rodgers
    • 1
  1. 1.Center for Fast Kinetics ResearchUniversity of Texas at AustinAustinUSA
  2. 2.Case Western Reserve UniversityUSA

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