Photophysical and Photodynamic Properties of New Photosensitizers
Currently, there is much research interest in new photosensitizers with intense far red optical absorptions. Such absorption properties would permit deeper penetration of exciting light into the skin and lower doses of photosensitizer. In our laboratory, we have been working in two areas with regard to these new photosensitizers. First, we are using time-resolved nanosecond flash photolysis to characterize excited states of these new, and also certain older, photosensitizers in vivo. Second, we are measuring the photodynamic cell killing of HeLa cells by two new photosensitizers, bis(tri-n-hexylsiloxy-2,3-naphthalocyanato) silicon (SiNC) (Firey and Rodgers, 1987) and bis(dibutyl-octadecylsiloxy-2,3-naphthalocyanato) silicon (BuSiNC).
KeywordsDifference Spectrum Exciting Light Mouse Myeloma Cell Hematoporphyrin Derivative DPPC Liposome
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- Firey PA, Rodgers MAJ (1987) Photo-properties of a silicon naphthalocya- nine: A potential photosensitizer for photodynamic therapy. Photochem Photobiol 45: 535–538Google Scholar