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Role of Ascorbate in Laminin Accumulation, Basement Membrane Deposition Acetylcholine Receptor Aggregation on Muscle

  • Z. Vogel
  • M. Krause
  • N. Rosenberg
  • Z. Y. Xi
  • T. K. Chen
  • M. P. Daniels
Conference paper
Part of the NATO ASI Series book series (volume 22)

Abstract

We have previously shown that embryonic brain, spinal cord and ciliary ganglia (CG) contain a low molecular weight factor (LMWF) which stimulates accumulation of collagens, including type IV (basement membrane collagen), on muscle cells in culture. The factor does this by increasing prolyl hydroxylase activity and is apparently equivalent to ascorbic acid (AA) (Kalcheim et al, 1985a, b).

Keywords

Ascorbic Acid Embryonic Brain Culture Muscle Cell Ciliary Ganglion Basement Membrane Collagen 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

  1. Kalcheim C, Duksin D, Bachar E, Vogel Z (1985a) Collagen stimulating factor from embryonic brain has ascorbate-like activity and stimulates prolyl hydroxylation in cultured muscle cells. Eur. J. Biochem. 146, 227–232.PubMedCrossRefGoogle Scholar
  2. Kalcheim C, Bachar E, Duksin D, Vogel Z (1985b) Ciliary ganglia and spinal cord release an ascorbate-like compound which stimulates proline hydroxylation and collagen formation in muscle cultures. Neurosci. Lett. 58, 219–224.PubMedCrossRefGoogle Scholar
  3. Daniels MP, Vigny M, Sonderegger P, Bauer HC, Vogel Z (1984) Association of laminin and other basement membrane components with regions of high acetylcholine receptor density on cultured myotubes. Int. J. Devel. Neurosci. 2, 87–99.CrossRefGoogle Scholar
  4. Kalcheim C, Vogel Z, Duksin D (1982) Embryonic brain extract induces collagen biosynthesis in cultured muscle cells: Involvement in acetylcholine receptor aggregation. Proc. Natl. Acad. Sci. USA 79, 3077–3081.PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1988

Authors and Affiliations

  • Z. Vogel
    • 1
  • M. Krause
    • 1
  • N. Rosenberg
    • 1
  • Z. Y. Xi
    • 2
  • T. K. Chen
    • 2
  • M. P. Daniels
    • 2
  1. 1.Neurobiology Dept.Weizmann Institute of ScienceRehovotIsrael
  2. 2.Lab. of Biochemical GeneticsNIHBethesdaUSA

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