Transplants of NGF-rich tissue increases survival and regeneration of axotomized cholinergic neurons in the basal forebrain
Transections of the fimbria-fornix (F/FX) result in a loss or shrinkage of cholinergic neurons in the medial septum/vertical limb of the diagonal band (MS/VDB) possibly due to the deprivation of a retrogradely transported, target-derived trophic factor(s) in the hippocampal formation. From recent evidence reported in this and other labs, it is suggested that one of these trophic factors may be nerve growth factor or NGF (Collins and Crutcher, 1985; Hefti, 1986; Gage et al, 1986; Springer et al, 1987). Specifically, we recently reported that the receptor to NGF is actively transported in the F/FX, thus establishing a mechanism by which NGF may mediate trophic support in the septo-hippocampal pathway (Johnson et al, 1987). Further, removal of target contact by transecting the F/FX results in a loss of MS/VDB neurons which are immunoreactive to the NGF receptor (Springer et al, 1987). We also have demonstrated that aspirations of the frontoparietal and anterior cingulate cortical areas result in cell loss or shrinkage in the nucleus basalis (Springer et al, 1987).
KeywordsNerve Growth Factor Cholinergic Neuron Basal Forebrain Trophic Factor Medial Septum
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- Sladek, J.R.,Jr. and Gash, D.M. (eds) (1984) Neural transplants development and function. Plenum Press, New York.Google Scholar