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Effects of Nerve Growth Factor and Monosialoganglioside GM1 on Forebrain Cholinergic Neurones

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Neural Development and Regeneration

Part of the book series: NATO ASI Series ((ASIH,volume 22))

Abstract

The relevance of cortical cholinergic innervation has attracted great interest since severe losses of choline acetyltransferase (ChAT) enzymatic activity and cell loss in the nucleus basalis of Meynert were demonstrated in the cerebral cortex of patients with Alzheimer’s disease (Coyle et al. 1983, Collerton 1986). In rats with unilateral cortical lesion specific biochemical and morphological retrograde changes occur in the nucleus basalis magnocellularis (NBM). Thirty days following devascularizing lesion of the cortex choline acetyl transferase (ChAT) activity in the NBM decreased significantly from control values while no significant change was noted in the neurochemical marker for GABAergic function glutamic acid decarboxylase (GAD).

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References

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Author information

Authors and Affiliations

  1. Department of Pharmacology and Therapeutics, McGill University, 3655 Drummond Street, Montreal, H3G 1Y6, Canada

    D. Maysinger, L. Garofalo & A. C. Cuello

Authors
  1. D. Maysinger
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  2. L. Garofalo
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  3. A. C. Cuello
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Editor information

Editors and Affiliations

  1. Istituto di Scienze Farmacologiche, FacoltĂ  di Farmacia, UniversitĂ  di Milano, Via Balzaretti 9, 20129, Milano, Italy

    A. Gorio

  2. Department of Human Biological Chemistry and Genetics, Marine Biomedical Institute, University of Texas Medical Branch, Galveston, TX, 77550, USA

    J. R. Perez-Polo

  3. Mental Retardation Research Center #68-177, Department of Anatomy and Department of Psychiatry and Biobehavioral Science, University of California, LA, 760 Westwood Plaza, Los Angeles, CA, 90024, USA

    J. de Vellis

  4. Department of Human Biological, Chemistry and Genetics and Department of Neurology, Marine Biomedical Institute, University of Texas Medical Branch, 200 University Blvd., #519, Galveston, TX, 77550, USA

    B. Haber

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© 1988 Springer-Verlag Berlin Heidelberg

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Maysinger, D., Garofalo, L., Cuello, A.C. (1988). Effects of Nerve Growth Factor and Monosialoganglioside GM1 on Forebrain Cholinergic Neurones. In: Gorio, A., Perez-Polo, J.R., de Vellis, J., Haber, B. (eds) Neural Development and Regeneration. NATO ASI Series, vol 22. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-73148-8_66

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  • DOI: https://doi.org/10.1007/978-3-642-73148-8_66

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-73150-1

  • Online ISBN: 978-3-642-73148-8

  • eBook Packages: Springer Book Archive

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