Advertisement

Effects of Nerve Growth Factor and Monosialoganglioside GM1 on Forebrain Cholinergic Neurones

  • D. Maysinger
  • L. Garofalo
  • A. C. Cuello
Part of the NATO ASI Series book series (volume 22)

Abstract

The relevance of cortical cholinergic innervation has attracted great interest since severe losses of choline acetyltransferase (ChAT) enzymatic activity and cell loss in the nucleus basalis of Meynert were demonstrated in the cerebral cortex of patients with Alzheimer’s disease (Coyle et al. 1983, Collerton 1986). In rats with unilateral cortical lesion specific biochemical and morphological retrograde changes occur in the nucleus basalis magnocellularis (NBM). Thirty days following devascularizing lesion of the cortex choline acetyl transferase (ChAT) activity in the NBM decreased significantly from control values while no significant change was noted in the neurochemical marker for GABAergic function glutamic acid decarboxylase (GAD).

Keywords

Nerve Growth Factor Cholinergic Neurone Glutamic Acid Decarboxylase Nucleus Basalis Osmotic Mini Pump 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

  1. Coyle JT, Price DL, DeLong MB (1983) Alzheimer’s disease: A disorder of cortical Cholinergic Innervation. Science 219:1184–1190.PubMedCrossRefGoogle Scholar
  2. Collerton D (1986) Cholinergic function and intellectual decline in Alzheimer’s disease. Neuroscience 19: 1–28.PubMedCrossRefGoogle Scholar
  3. Cuello AC, Stephens PH, Tagari PD, Sofroniew MV, Pearson RCA (1986) Retrograde changes in the nucleus basalis of the rat caused by cortical damage are prevented by exogenous ganglioside GM1. Brain Research 376: 373–377.PubMedCrossRefGoogle Scholar
  4. Eckenstein F, Thoenen H (1982) Production of specific antisera and monoclonal antibodies in choline acetyltransferase. Characterization and use for identification of cholinergic neurones. EMBO J 1: 363–368.PubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1988

Authors and Affiliations

  • D. Maysinger
    • 1
  • L. Garofalo
    • 1
  • A. C. Cuello
    • 1
  1. 1.Department of Pharmacology and TherapeuticsMcGill UniversityMontrealCanada

Personalised recommendations