Effects of Nerve Growth Factor and Monosialoganglioside GM1 on Forebrain Cholinergic Neurones
The relevance of cortical cholinergic innervation has attracted great interest since severe losses of choline acetyltransferase (ChAT) enzymatic activity and cell loss in the nucleus basalis of Meynert were demonstrated in the cerebral cortex of patients with Alzheimer’s disease (Coyle et al. 1983, Collerton 1986). In rats with unilateral cortical lesion specific biochemical and morphological retrograde changes occur in the nucleus basalis magnocellularis (NBM). Thirty days following devascularizing lesion of the cortex choline acetyl transferase (ChAT) activity in the NBM decreased significantly from control values while no significant change was noted in the neurochemical marker for GABAergic function glutamic acid decarboxylase (GAD).