Influence of Neurotrophic Factors on the Phosphorylation of Extracellular Proteins

  • Anke-Peggy Holtorf
  • Klaus Unsicker
  • Hans-Dieter Hofmann
Conference paper
Part of the NATO ASI Series book series (volume 22)


Extracts from bovine seminal vesicles have been shown to contain two neurotrophic factors (NTFs), nerve growth factor (NGF) and seminal vesicle derived growth factor (SVNF, Hofmann and Unsicker, 1982 and 1987). Both polypeptide factors address the same spectrum of target cells and are indistinguishable with regard to their biological effects. Their molecular properties, however, are clearly different, and there is some evidence that they exert their trophic effects via different biochemical mechanisms. Here, we present evidence for the dependence of an extracellular phosphoprotein on the synergistic action of NGF and SVNF.


Nerve Growth Factor Neurotrophic Factor Seminal Vesicle Chromaffine Cell Extracellular Protein 
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  1. Hofmann H.-D., Unsicker K (1982) The seminal vesicle of the bull: A new and very rich source of nerve growth factor. Eur.J.Biochem. 128:421–426PubMedCrossRefGoogle Scholar
  2. Hofmann H.-D., Unsicker K (1987) Characterization and partial purification of a novel neuronotrophic factor from bovine vesicle. J.Neurochem., in pressGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1988

Authors and Affiliations

  • Anke-Peggy Holtorf
    • 1
  • Klaus Unsicker
    • 1
  • Hans-Dieter Hofmann
    • 2
  1. 1.Institut für Anatomie und ZellbiologiePhilipps Universität MarburgMarburgGermany
  2. 2.Max-Planck-Institut für HirnforschungFrankfurt/MainGermany

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