Influence of Neurotrophic Factors on the Phosphorylation of Extracellular Proteins
Extracts from bovine seminal vesicles have been shown to contain two neurotrophic factors (NTFs), nerve growth factor (NGF) and seminal vesicle derived growth factor (SVNF, Hofmann and Unsicker, 1982 and 1987). Both polypeptide factors address the same spectrum of target cells and are indistinguishable with regard to their biological effects. Their molecular properties, however, are clearly different, and there is some evidence that they exert their trophic effects via different biochemical mechanisms. Here, we present evidence for the dependence of an extracellular phosphoprotein on the synergistic action of NGF and SVNF.
KeywordsHydrolysis Serine Polypeptide Neuroblastoma Coomassie
- Hofmann H.-D., Unsicker K (1987) Characterization and partial purification of a novel neuronotrophic factor from bovine vesicle. J.Neurochem., in pressGoogle Scholar