Fetal Spinal Cord Homografts Reduce Expected Hind Limb Deficits from Spinal Cervical Fasiculus Gracilis Lesion

  • Jerald J. Bernstein
  • William J. Goldberg
Conference paper
Part of the NATO ASI Series book series (volume 22)


Dorsal column (DC) lesion at T13 resulted in a reorganization of the synaptic circuitry in the rat DC-lemniscal system and somatomotor cortex. This lesion resulted in hind limb slips from a platform that appear 60–120 days after the lesion1. The present study explored the ability of fetal spinal cord grafts into C3 fasiculus gracilis (FG; similar to a T13 DC lesion) to influence hind limb performance.


Hind Limb Central Nervous System Injury Dorsal Column Thoracic Spinal Cord Nucleus Gracilis 
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  1. 1.
    Bernstein JJ.,Ganchrow D, Wells M (1983) Nervous System Regeneration, (Giuffrida-Stella A eds.), Alan R. Liss, NY 135-149Google Scholar
  2. 2.
    Goldberg W. Bernstein JJ (1987) Transplant derived astrocytes migrate into host lumbar and cervical spinal cord after implantation of E14 fetal cerebral cortex into adult thoracic spinal cord. J Neurosci Res 17: (in press).Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1988

Authors and Affiliations

  • Jerald J. Bernstein
    • 1
  • William J. Goldberg
    • 2
  1. 1.Laboratory of Central Nervous System Injury and RegenerationVA Medical CenterUSA
  2. 2.Departments of Neurosurgery and PhysiologyGeorge Washington UniversityUSA

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