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Role of Factors Intrinsic and Extrinsic to CNS Regulating IntraSpinal Degenerative-Atrophy Following Sciatic Nerve Injury

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Neural Development and Regeneration

Part of the book series: NATO ASI Series ((ASIH,volume 22))

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Abstract

Morphological, immunocytochemical, biochemical and electrophysiological correlates have indicated that the laminae I and II of the spinal cord dorsal horn constitute a complex system playing an important role in endogenous pain control mechanisms (1). The area contains a variety of neuroactive peptides which, as shown by immunocytochemical studies are distintly located in the axon terminals of the peripheral sensory imputs, in a wide population of local interneurons and in the central descending pathways (1,2,3,4,5). Such a complex anatomical organization displays a remarkable capacity of rearrangements. Peripheral nerve lesions cause profound changes in the sensory maps of the dorsal horn (6), suggesting alterations of both sensory imputs and local interneurons. It was, indeed, shown that section of the sciatic nerve induces a significant drop of substance P sensory imput and of met-enkephalin contained in dorsal horn interneurons (5, 7).

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Author information

Authors and Affiliations

  1. Department of Medical Pharmacology, University of Milano, Via Vanvitelli 32, Milano, 20129, Italy

    Anna Maria Di Giulio, Antonella Mannavola, Beatrice Tenconi & Paolo Mante-Gazza

  2. School of Pharmacology, Institute of Pharmacological Sciences, Via Balzaretti 9, Milano, 20129, Italy

    Alfredo Gorio

Authors
  1. Anna Maria Di Giulio
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  2. Antonella Mannavola
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  3. Beatrice Tenconi
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  4. Paolo Mante-Gazza
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  5. Alfredo Gorio
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Editor information

Editors and Affiliations

  1. Istituto di Scienze Farmacologiche, Facoltà di Farmacia, Università di Milano, Via Balzaretti 9, 20129, Milano, Italy

    A. Gorio

  2. Department of Human Biological Chemistry and Genetics, Marine Biomedical Institute, University of Texas Medical Branch, Galveston, TX, 77550, USA

    J. R. Perez-Polo

  3. Mental Retardation Research Center #68-177, Department of Anatomy and Department of Psychiatry and Biobehavioral Science, University of California, LA, 760 Westwood Plaza, Los Angeles, CA, 90024, USA

    J. de Vellis

  4. Department of Human Biological, Chemistry and Genetics and Department of Neurology, Marine Biomedical Institute, University of Texas Medical Branch, 200 University Blvd., #519, Galveston, TX, 77550, USA

    B. Haber

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© 1988 Springer-Verlag Berlin Heidelberg

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Di Giulio, A.M., Mannavola, A., Tenconi, B., Mante-Gazza, P., Gorio, A. (1988). Role of Factors Intrinsic and Extrinsic to CNS Regulating IntraSpinal Degenerative-Atrophy Following Sciatic Nerve Injury. In: Gorio, A., Perez-Polo, J.R., de Vellis, J., Haber, B. (eds) Neural Development and Regeneration. NATO ASI Series, vol 22. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-73148-8_33

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  • DOI: https://doi.org/10.1007/978-3-642-73148-8_33

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-73150-1

  • Online ISBN: 978-3-642-73148-8

  • eBook Packages: Springer Book Archive

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