Role of Factors Intrinsic and Extrinsic to CNS Regulating IntraSpinal Degenerative-Atrophy Following Sciatic Nerve Injury

  • Anna Maria Di Giulio
  • Antonella Mannavola
  • Beatrice Tenconi
  • Paolo Mante-Gazza
  • Alfredo Gorio
Conference paper
Part of the NATO ASI Series book series (volume 22)


Morphological, immunocytochemical, biochemical and electrophysiological correlates have indicated that the laminae I and II of the spinal cord dorsal horn constitute a complex system playing an important role in endogenous pain control mechanisms (1). The area contains a variety of neuroactive peptides which, as shown by immunocytochemical studies are distintly located in the axon terminals of the peripheral sensory imputs, in a wide population of local interneurons and in the central descending pathways (1,2,3,4,5). Such a complex anatomical organization displays a remarkable capacity of rearrangements. Peripheral nerve lesions cause profound changes in the sensory maps of the dorsal horn (6), suggesting alterations of both sensory imputs and local interneurons. It was, indeed, shown that section of the sciatic nerve induces a significant drop of substance P sensory imput and of met-enkephalin contained in dorsal horn interneurons (5, 7).


Sciatic Nerve Dorsal Horn Lumbar Spinal Cord Spinal Cord Dorsal Horn Phantom Limb Pain 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1988

Authors and Affiliations

  • Anna Maria Di Giulio
    • 1
  • Antonella Mannavola
    • 1
  • Beatrice Tenconi
    • 1
  • Paolo Mante-Gazza
    • 1
  • Alfredo Gorio
    • 2
  1. 1.Department of Medical PharmacologyUniversity of MilanoMilanoItaly
  2. 2.School of PharmacologyInstitute of Pharmacological SciencesMilanoItaly

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