Molecular Aspects of the Rat Nerve Growth Factor Receptor

  • T. P. Misko
  • M. J. Radeke
  • E. M. Shooter
Conference paper
Part of the NATO ASI Series book series (volume 22)

Abstract

The role of nerve growth factor (NGF) in the development, maintenance, and regrowth (after injury) of sympathetic and some sensory neurons is well documented (Vale and Shooter 1987, Oppenheim 1981, Levi-Montalcini and Angeletti 1968). perhaps this is most strikingly demonstrated by the ability of NGF antibodies to prevent the development of sympathetic neurons when injected into newborn rats (Levi-Montalcini and Angeletti, 1966) or of some sensory neurons when introduced into the fetus (Johnson et al. 1980). More recently, the discovery of NGF in certain cholinergic systems in the brain suggests a similar role for NGF in specific CNS neurons (Korsching et al. 1985).

Keywords

Codon Cysteine Sarcoma Trypsin Choline 

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References

  1. Alema S, Casalbore P, Agostini E, Tato F (1985) Differentiation of PC12 pheochromocytoma cells induced by v-src oncogene. Nature 316: 557–559.PubMedCrossRefGoogle Scholar
  2. Bar-Sagi D, Feramisco JR (1985) Microinjection of the ras oncogene into PC12 cells induces morphological differentiation. Cell 42: 841–848.PubMedCrossRefGoogle Scholar
  3. Bernd P, Greene LA (1984) Association of 125I-nerve growth factor with PC12 pheochromocytoma cells. J Biol Chem 259: 15509–15516.PubMedGoogle Scholar
  4. Bothwell MA, Shooter EM (1977) Dissociation equilibrium constant of β-nerve growth factor. J Biol Chem 252: 8532–8536.PubMedGoogle Scholar
  5. Buck CR, Chao MV, Martinez HJ, Black IB (1986) Selective expression of the nerve growth factor receptor gene in vivo. Neuroscience Abst 111.2:391.Google Scholar
  6. Chao MV, Bothwell MA, Ross AH, Koprowski H, Lanahan AA, Buck CR, Sehgal A (1986) Gene transfer and molecular cloning of the human NGF receptor. Science 232: 518–521.PubMedCrossRefGoogle Scholar
  7. Darling TL, Petrides PE, Beguin E, Frey P, Shooter EM (1983) The biosynthesis and processing of proteins in the mouse 7S nerve growth factor complex. Cold Spring Harbor Symp. Quant. Biol 48: 427–434.Google Scholar
  8. Dumas M, Schwab ME, Thoenen H (1979) Retrograde axonal transport of specific macromolecules as a tool for characterizing nerve terminal membranes. J Neurobiology 10: 179–197.CrossRefGoogle Scholar
  9. Edwards RH, Selby MJ, Rutter WJ (1986) Differential RNA splicing predicts two distinct nerve growth factor precursors. Nature 319: 784–786.PubMedCrossRefGoogle Scholar
  10. Green SH, Greene LA (1986) A single Mr 103,000 125I-β”Nerve Growth Factor-affinity-labeled species represents both the low and high affinity forms of the nerve growth factor receptor. J. Biol. Chem. 261: 15316–15326.PubMedGoogle Scholar
  11. Grob PM and Bothwell MA (1983) Modification of nerve growth factor receptor properties by wheat germ agglutinin. J Biol Chem 258: 14136–14143.PubMedGoogle Scholar
  12. Hagag N, Halegoua S, Viola M (1986) Inhibition of growth factor- induced differentiation of PC12 cells by microinjection of antibody to p21. Nature 319: 680–682.PubMedCrossRefGoogle Scholar
  13. Hedrick, SM, Cohen, DI, Nielsen, EA, Davis, MM (1984) Isolation of cDNA clones encoding T cell-specific membrane associated proteins. Nature 308: 149–153.PubMedCrossRefGoogle Scholar
  14. Heumann R, Schwab M, Thoenen H (1981) A second messenger required for nerve growth factor biological activity? Nature 292: 838–840.PubMedCrossRefGoogle Scholar
  15. Heumann R, Schwab M, Merkl R, Thoenen H (1984) Nerve growth factor - mediated induction of choline acetyltransferase in PC12 cells: Evaluat ion of the site of action of nerve growth factor and the involvement of lysosomal degradation products of nerve growth factor. J. Neuroscience 4: 3039–3050.Google Scholar
  16. Hosang M, Shooter EM (1985) Molecular characteristics of nerve growth factor receptors on PC12 cells. J Biol Chem 260: 655–662.PubMedGoogle Scholar
  17. Hosang M, Shooter EM (1987) The internalization of nerve growth factor by high-affinity receptors on pheochromocytoma PC12 cells. EMBO J 6: 1197–1202.PubMedGoogle Scholar
  18. Johnson D, Lanahan A, Buck CR, Sehgal A, Morgan C, Mercer E, Bothwell M, Chao M, (1986) Expression and structure of the human NGF receptor. Cell 47: 545–554.PubMedCrossRefGoogle Scholar
  19. Johnson EM Jr, Gorin PD, Brandeis LD, Pearson J (1980) Dorsal root ganglion neurons are destroyed by exposure in utero to maternal antibody to nerve growth factor. Science 210: 916–918.PubMedCrossRefGoogle Scholar
  20. Korsching S, Thoenen H (1983) Quantitative demonstration of the retrograde axonal transport of endogenous nerve growth factor. Neuroscience Letter 39: 1–4.CrossRefGoogle Scholar
  21. Korsching S, Thoenen H. (1983) Nerve growth factor in sympathetic ganglia and corresponding target organs of the rat correlates with density of sympathetic innervation. Proc. Natl. Acad. Sci. U.S.A. 80: 3513–3516PubMedCrossRefGoogle Scholar
  22. Korsching S, Thoenen H (1985) Treatment with 6–hydroxydopamine and colchicine decreases nerve growth factor levels in sympathetic ganglia and increases them in corresponding target tissues. J. Neuroscience 5: 1058–1061.Google Scholar
  23. Korsching S, Auburger G, Heumann R, Scott J, Thoenen H (1985) Levels of nerve growth factor and its mRNA in the central nervous system of the rat correlate with cholinergic innervation. EMBO J 4: 1389–1393.PubMedGoogle Scholar
  24. Layer PG, Shooter EM (1973) Binding and degradation of nerve growth factor by PC12 pheochromocytoma cells. J Biol Chem 258: 3012–3018.Google Scholar
  25. Levi-Montalcini R, Angeletti P.U. (1966) Immunosympathectomy. Pharmacol Rev 18, 619–628.PubMedGoogle Scholar
  26. Levi-Montalcini R, Angeletti P.U. (1968) Nerve Growth Factor. Physiol Rev 48, 534–569.PubMedGoogle Scholar
  27. Noda M, Ko M, Ogura A, Lin D-G, Amano T, Takano T, Ikawa Y (1985) Sarcoma viruses carrying ras oncogenes induce differentiation associated properties in a neuronal cell line. Nature 318: 73–75.PubMedCrossRefGoogle Scholar
  28. Oppenheim RW (1981) Neuronal cell death and some related phenomena during neurogenesis: A selective historical review and progress report. In Studies In Developmental Biology (ed WM Cowan) New York, Oxford: Oxford University Press, pp. 74–133.Google Scholar
  29. Radeke MJ, Misko TP, Hsu C, Herzenberg LA, Shooter EM (1987) Gene transfer and molecular cloning of the rat nerve growth factor receptor: a new class of receptors. Nature 325: 593–597.PubMedCrossRefGoogle Scholar
  30. Schechter AL, Bothwell MA (1981) Nerve growth factor receptors on PC12 cells: Evidence for two receptor classes with differing cytoskeletal association. Cell 24: 867–874.PubMedCrossRefGoogle Scholar
  31. Seeley PJ, Keith CH, Shelanski ML, Greene LA (1983) Pressure microinjection of nerve growth factor and anti-nerve growth factor into the nucleus and cytoplasm: Lack of effects on neurite outgrowth from pheochromocytoma cells. J. Neuroscience 3: 1488–1494.Google Scholar
  32. Shelton DL, Reichardt LF (1984) Expression of the g-nerve growth factor gene correlates with the density of sympathetic innervation in effector organs. Proc Natl Acad Sci USA 81: 7951–7955.PubMedCrossRefGoogle Scholar
  33. Shooter EM, Yankner BA, Landreth GE, Sutter A (1981) Recent Prog Hormone Res. Biosynthesis and Mechanism of action of nerve growth factor. 37: 417–446.Google Scholar
  34. Vale RD, Chandler CE, Sutter A, Shooter EM (1983) The binding and internalization of nerve growth factor. In Receptors and Recognition, edited by P Cuatrecasas and MF Greaves, London: Chapman and Hall, pp. 83–119.Google Scholar
  35. Vale RD, Shooter EM (1982) Alteration of binding properties and cytoskeletal attachment of nerve growth factor receptors in PC12 cells by wheat germ agglutinin. J.Cell Biol 94: 710–717.PubMedCrossRefGoogle Scholar
  36. Vale RD, Shooter EM (1983) Conversion of nerve growth factor receptor complexes to a slowly dissociating, Triton X-100 insoluble state by anti-nerve growth factor antibodies. Biochemistry 22: 5022–5028.PubMedCrossRefGoogle Scholar
  37. Vale RD, Shooter EM (1987) Nerve Growth Factor. In Cowan WM (ed) Handbook of Physiology. Baltimore Waverly Press, in press.Google Scholar
  38. Wigler M, Silverstein S, Lee L-S, Pelicer A, Cheng Y-C, Axel R (1979) Transfer of purified herpes virus thymidine kinase gene to cultured mouse cells. Cell 11: 223–232.CrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1988

Authors and Affiliations

  • T. P. Misko
    • 1
  • M. J. Radeke
    • 1
  • E. M. Shooter
    • 1
  1. 1.Department of NeurobiologyStanford University School of MedicineStanfordUSA

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