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Neural Development and Regeneration pp 167–182Cite as

Adaptive Changes in an Animal Model of Micro-Encephaly

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Part of the book series: NATO ASI Series ((ASIH,volume 22))

Abstract

As a result of pre-natal or early post-natal exposure to a variety of agents (viruses, irradiation and cytotoxins) humans may develop microencephaly, characterized by reduction of brain size (Crome & Stern, 1967), with different involvement of selective brain regions depending on the type of agent and duration of exposure. Since neurons in different brain areas undergo their final division at quite distinct times during C.N.S. development, interference with neurogenesis will result in different kinds of brain lesions, strictly depending upon time of the insult, being actively dividing cells more affected than differentiated neurons. This mechanism is at the base of the neuronal lesions induced perinatally by cytotoxic agents such as hydroxy-urea, 5-azacytidine and methyl-azoxy-methanol acetate (MAM), which selectively interfere with DNA synthesis (Jonhston & Coyle, 1982). As a consequence of these lesions, the developing and maturing brain seems to undergo a series of adaptive changes not yet fully characterized, and whose consequences are totally unknown.

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References

  • Angevine JB, Sidman RL (1961) Autoradiographic study of cell migration during histogenesis of cerebral cortex in the mouse. Nature 192: 766–768

    Article  PubMed  Google Scholar 

  • Balduini W, Abbracchio MP, Lombardelli G, Cattabeni F (1984). Loss of intrinsic striatal neurons after methyl-azoxy-methanol acetate treatment in pregnant rats. Dev Brain Res 15: 133–136

    Article  CAS  Google Scholar 

  • Balduini W, Cimino M, Lombardelli G, Abbracchio MP, Peruzzi G, Cecchini T, Gazzanelli GC, Cattabeni F (1986) Micro-encephalic rats as a model for cognitive disorders. Clin Neuropharmacol 9(3): S8–18

    Google Scholar 

  • Banfi S, Dorigotti L, Abbracchio MP, Balduini W, Coen E, Ragusa C, Cattabeni F (1984) Methyl-azoxy-methanol micro-encephaly in rats: neurochemical characterization and behavioral studies with the nootropic oxiracetam. Pharmacol Res Comm 16(1): 67–83

    CAS  Google Scholar 

  • Beaulieu M, Coyle JT (1981) Effects of fetal methyl-azoxy-methanol acetate lesion on the synaptic neurochemistry of the adult rat striatum. J Neurochem 37(4): 878–887

    Article  PubMed  CAS  Google Scholar 

  • Beaulieu M, Coyle JT (1982) Fetally-induced noradrenergic hyperinner-vation of cerebral cortex results in persistent down-regulation of beta-receptors. Dev Brain Res 4: 491–494

    Article  Google Scholar 

  • Cannon-Spoor EH, Freed WJ (1984) Hyperactivity induced by prenatal administration of methyl-azoxy-methanol: association with altered performance on conditioning tasks in rats. Pharmacol Biochem and Behavior 20: 189–193

    Article  CAS  Google Scholar 

  • Cattabeni F, Galli CL, Eros T (1976) A simple and highly sensitive mass-fragmentographic procedure for γ -aminobutyricacid determinations. Anal Biochem 72: 1–7

    Article  PubMed  CAS  Google Scholar 

  • Crome L, Stern J (1967) The pathology of mental retardation, Churchill, London

    Google Scholar 

  • Eriksdotter-Nilsson M, Jonsson G, Dahl D, Bjorklund H (1986) Stroglial development in microencephalic rat brain after fetal methyl-azoxy-methanol treatment. J Devi Neurosci 4(4); 353–362

    Article  CAS  Google Scholar 

  • Giurgea C, Mouravieff-LeSuisse F (1972) Effect facilitateur du piracetam sur un apprentissage repetitif chez le rat. J. Pharmacol 3(1): 17–30

    CAS  Google Scholar 

  • Haddad RK, Rabe A, Laquer GL, Spatz M, Valsamis MP (1969) Intellectual deficit associated with transplacentally induced microcephaly in the rat. Science 163: 88–90

    Article  PubMed  CAS  Google Scholar 

  • Johnston MV, Carman AB, Coyle JT (1981) Effects of fetal treatment with methyl-azoxy-methanol acetate at various gestational dates on the neurochemistry of the adult neocortex of the rat. J Neurochem 36(1): 124–128

    Article  PubMed  CAS  Google Scholar 

  • Johnston MV, Coyle JT (1982) Cytotoxic lesion and the development of transmitter systems. TINS May: 153–156

    Google Scholar 

  • Koslow SH, Cattabeni F, Costa E (1972) Norepinephrine and dopamine: assay by mass-fragmentography in the picomole range. Science 176: 177–180

    Article  PubMed  CAS  Google Scholar 

  • Kurland LT (1972) An appraisal of the neurotoxicity of cycad and the etiology of amiotrophic lateral sclerosis on Guam. Fed Proc 31(5): 1540–1542

    PubMed  CAS  Google Scholar 

  • Lee MH, Haddad R, Rabe A (1982) Impaired learning of the Lasheley II maze by rats with chemically induced micrencephaly. Teratol 25: 58–59

    Article  Google Scholar 

  • Lo Conte G, Bartolini L, Casamenti F, Marconcini-Pepeu I, Pepeu G (1982) Lesions of cholinergic forebrain nuclei: changes in avoidance behaviour and scopolamine actions. Pharmacol Biochem & Behavior 17: 933–937

    Article  CAS  Google Scholar 

  • Matsutani T, Nagayoshi M, Tamaru M, Tsukada Y (1980) Elevated monoamine levels in the cerebral hemispheres of microencephalic rats treated prenatally with methy1–azoxy-methanol or cytosine arabinoside. J Neurochem 34(4): 950–956

    Article  PubMed  CAS  Google Scholar 

  • Mohammed AK, Jonsson G, Sundstrom E, Minor BG, Soderberg U, Archer T (1986) Selective attention and place navigation in rats treated prenatally with methy1–azoxy-methanol. Dev Brain Res 30: 145–155

    Article  CAS  Google Scholar 

  • Morrison JH, Rogers J, Scherr S, Benoit R, Bloom FE (1985) Somatostatin immunoreactivity in neuritic plaques of Alzheimer’s patients. Nature 314: 90–92

    Article  PubMed  CAS  Google Scholar 

  • Petraglia F, Locatelli V, Penalva A, Cocchi D, Genazzani AR, Muller EE (1984) Gonadal steroid modulation of naloxone-induced LH secretion in the rat. J Endocr 101: 33–39

    Article  PubMed  CAS  Google Scholar 

  • Roberts GW, Crow TJ, Polak JM (1985) Location of neuronal tangles in somatostatin neurons in Alzheimer’s disease. Nature 314: 92–94

    Article  PubMed  CAS  Google Scholar 

  • Sanberg PR, Pevsner J, Antuono PG, Coyle JT (1985) Fetal methyl-azoxy-methanol acetate-induced lesions cause reductions in dopamine receptor-mediated catalepsy and stereotypy. Neuropharmacol 24(11): 1057–1062

    Article  CAS  Google Scholar 

  • Vorhees CV, Fernandez K, Dumas RM, Haddad RK (1984) Pervasive hyperactivity and long-term learning impairments in rats with induced micrencephaly from prenatal exposure to methyl-azoxy-methanol. Dev Brain Res 15: 1–10

    Article  CAS  Google Scholar 

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Author information

Authors and Affiliations

  1. Institute of Pharmacological Sciences, School of Pharmacy, University of Milano, Italy

    F. Cattabeni, M. Cimino, M. Di Luca, L. Mennuni, P. Zaratin & M. P. Abbracchio

  2. Department of Pharmacology, School of Medicine, University of Milano, Italy

    D. Cocchi

Authors
  1. F. Cattabeni
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  2. D. Cocchi
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  3. M. Cimino
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  4. M. Di Luca
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  5. L. Mennuni
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  6. P. Zaratin
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  7. M. P. Abbracchio
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Editor information

Editors and Affiliations

  1. Istituto di Scienze Farmacologiche, Facoltà di Farmacia, Università di Milano, Via Balzaretti 9, 20129, Milano, Italy

    A. Gorio

  2. Department of Human Biological Chemistry and Genetics, Marine Biomedical Institute, University of Texas Medical Branch, Galveston, TX, 77550, USA

    J. R. Perez-Polo

  3. Mental Retardation Research Center #68-177, Department of Anatomy and Department of Psychiatry and Biobehavioral Science, University of California, LA, 760 Westwood Plaza, Los Angeles, CA, 90024, USA

    J. de Vellis

  4. Department of Human Biological, Chemistry and Genetics and Department of Neurology, Marine Biomedical Institute, University of Texas Medical Branch, 200 University Blvd., #519, Galveston, TX, 77550, USA

    B. Haber

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© 1988 Springer-Verlag Berlin Heidelberg

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Cattabeni, F. et al. (1988). Adaptive Changes in an Animal Model of Micro-Encephaly. In: Gorio, A., Perez-Polo, J.R., de Vellis, J., Haber, B. (eds) Neural Development and Regeneration. NATO ASI Series, vol 22. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-73148-8_15

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  • DOI: https://doi.org/10.1007/978-3-642-73148-8_15

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-73150-1

  • Online ISBN: 978-3-642-73148-8

  • eBook Packages: Springer Book Archive

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