Abstract
Neuronal sensitivity to nerve growth factor (NGF) is conferred by the presence of specific high affinity receptors (Stach and Perez-Polo, 1987). Based on immunocytochemical and autoradiographic stud ies of adult rat and human brains, NGF receptors (NGF-R) are known to be present on cholinergic neurons located in the basal forebrain and on their terminals in the neocortex and hippocampus (Schwab et al., 1979; Seiler and Schwab, 1984; Hefti et al., 1986; Richardson et al., 1986; Johnson et al., 1987; Raivich and Kreutzberg, 1987; Springer et al, 1987; Loy et al, in press). In addition, measurement of NGF-R by immunoprecipitation reveals the presence of significant quantities of NGF-R in rat cerebellum, thalamus, olfactory bulb, and particularly in the brainstem (Taniuchi et al., 1986b). Recently, NGF-R have also been identified autoradiographically on a variety of neurons in the rat brainstem, including those of the cochlear nucleus and nucleus of the lateral lemniscus, components of the auditory system, suggesting that some central sensory neurons may be sensitive to NGF (Richardson et al., 1986; Raivich and Kreutzberg, 1987).
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
Similar content being viewed by others
References
Ayer-Leiievre CS, Ebendal T, Olson L, Seiger A (1983) Localization of nerve growth factor-like immunoreactivity in rat nervous tissue. Med Biol 61:296–304
Bruckner G, Mares V, Biesold M (1976) Neurogenesis in the visual system of the rat. An autoradiographic investigation. J Comp Neurol 166:245–256
Hefti F, Hartikka J, Salvatierra A, Weiner WJ, Mash DC (1986) Localization of nerve growth factor receptors in choliner gic neurons of the human basal forebrain. Neurosci Let 69:37–41
Heumann R, Korsching S, Bandtlow C, Thoenen H (to be published) Changes of nerve growth factor synthesis in nonneuron al cells in response to sciatic nerve transection. J Cell Biol
Jones EG (1981) Development of connectivity in the cerebral cortex. In:Cowan WM (ed) Studies in Developmental Neurobiology. Oxford University Press, New York Oxford, p 354
Levi-Montalcini R, Aloe L (1985) Differentiating effects of murine nerve growth factor in the peripheral and central nervous systems of Xenopus laevis tadpoles. Proc Natl Acad Sci USA 82:7111–7115
Loy R, Springer JE, Tayrien MW, Koh S (to be published) Septal and lesion-induced sympathetic afferents to the hippocampus are immunoreactive for nerve growth factor receptor. Exper Neurol
Lund RD, Bunt AH (1976) Prenatal development of central optic pathways in albino rats. J Comp Neurol 165:247–264
Lund RD, Mustari MJ (1977) Development of the geniculocortical pathway in rats. J Comp Neurol 173:289–305
Raivich G, Kreutzberg GW (1987) The localization and distribution of high affinity beta-nerve growth factor binding sites in the central nervous system of the adult rat. A light microscopic autoradiographic study using [1251]beta-nerve growth factor. Neurosci 20:23–36
Raivich G, Zimmermann A, Sutter A (1985) The spatial and temporal pattern of beta-NGF receptor expression in the developing chick embryo. EMBO J 4:637–644
Richardson PM, Verge Issa VMK, Riopelle RJ (1986) Distribution of neuronal receptors for nerve growth factor in the rat. J Neurosci 6:2312–2321
Rohrer H, Barde Y-A (1982) Presence and disappearance of nerve growth factor receptors on sensory neurons in culture. Devel Biol 89:309–315
Springer JE, Koh S, Tayrien MW, Loy R (1987) Basal forebrain magnocellular neurons stain for nerve growth factor receptor: correlation with cholinergic cell bodies and effects of axotomy. J Neurosci Res 17:111–118
Stach RW, Perez-Polo JR (1987) Binding of nerve growth factor to its receptor. J Neurosci Res 17:1–10.
Taniuchi M, Clark HB, Johnson EM Jr (1986a) Induction of nerve growth factor receptor in Schwann cells after axotomy. Proc Natl Acad Sci USA 83:4094–4098
Taniuchi M, Johnson EM Jr (1985) Characterization of the binding properties and retrograde axonal transport of a monoclonal antibody directed against the rat nerve growth factor receptor. J Cell Biol 101:1100–1106
Taniuchi M, Schweitzer JB, Johnson EM Jr (1986b) Nerve growth factor receptor molecules in rat brain. Proc Natl Acad Sci USA 83:1950–1954
Yan Q and Johnson EM Jr (1987) A quantitative study of the developmental expresssion of nerve growth factor (NGF) receptor in rats. Devel Biol 121:139–148
Zimmermann A, Sutter A (1983) Beta-nerve growth factor (beta- NGF) receptors on glial cells. Cell-cell interaction between neurons and Schwann cells in cultures of chick sensory ganglia EMBO J 2:879–885
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1988 Springer-Verlag Berlin Heidelberg
About this paper
Cite this paper
Loy, R., Koh, S. (1988). Expression of NGF Receptors During Development of Central Sensory Pathways in the Rat. In: Gorio, A., Perez-Polo, J.R., de Vellis, J., Haber, B. (eds) Neural Development and Regeneration. NATO ASI Series, vol 22. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-73148-8_10
Download citation
DOI: https://doi.org/10.1007/978-3-642-73148-8_10
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-73150-1
Online ISBN: 978-3-642-73148-8
eBook Packages: Springer Book Archive