Towards Cognitive Immunology : G.O.D. is Infinite

  • Nelson M. Vaz
Part of the NATO ASI Series book series (volume 23)


The meeting in Immunosemiotics was a rare opportunity to take a fresh look into immunological problems. It was possible, for instance, to define them as cognitive problems -i.e.: problems involving the interpretation, computation and generation of knowledge. It is true that only in a few moments during the meeting this possibility was clearly brought forth; but a few important statements were made in this direction, and I will use this contribution to reinforce this view. This will be an effort of the so trancisco Varela has called “… the difficult-process of addressing foundational issues at an unreceptive time.”(1). And this will be so because we live in a tradition which, although usually invisible, influences our ways of delineating problems and our criteria of validation of hypotheses and results.


Internal Image Specific Lymphocyte Network Idea External Image Foundational Issue 
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  1. 1.
    Varela, F.J. (1986) Experimental epistemology:Background and future. In Cognition et Complexité,Cahiers du CREA 9: 107–122Google Scholar
  2. 2.
    Jerne, N.K. (1974) Towards a network theory of the immune system Ann. immunol (Paris) 125C: 373–395.Google Scholar
  3. 3.
    Jerne, N.K. (1976) The immune system: a web of V-domains. Harvey Lectures 70:93–110.Google Scholar
  4. 4.
    Vaz, N.M. and Varela, F.J. (1978) Self and nonSense:an organismcentered approach to immunology. Med. Hypotheses :231–257.Google Scholar
  5. 5.
    Piaget, J. (1967) Biologie et Connaissance, Gallimard, Paris.Google Scholar
  6. 6.
    Piaget, J. (1976) Comportement:Moteur de l’Evolution, Gallimard, Paris.Google Scholar
  7. 7.
    Jerne, N.K. (1955)The natural selection theory of antibody formation. Proc. Natl. Acad. Sci. U.S.A. 41: 849–860.CrossRefGoogle Scholar
  8. 8.
    Inman, J.K. (1978) The antibody-combining region:speculations on the hypothesis of general multispecificity. In G.A. Bell, A.S. Perelson,and G.H. Pimbley,eds. Theoretical Immunology, Marcel Dekker, New York, p 243–278.Google Scholar
  9. 9.
    Maturana, H.R. and Varela, F.J. (1980) Autopoiesis and Cognition: The realization of the Living. Reidel, Amsterdan.Google Scholar
  10. 10.
    Varela, F.J. (1979) Principles of Biological Autonomy. Elsevier, North-Holland, Amsterdan.Google Scholar
  11. 11.
    Maturana, H.R.and Varela, F.J. (1987) The tree of knowledge: the biological basis of human uderstanding. New Science Library, Boston.Google Scholar
  12. 12.
    Freitas, A.A., Rocha, B.and Coutinho, A. (1986) Lymphocyte population kinetics in the mouse. Immunol.Rev. 91: 5–37.PubMedCrossRefGoogle Scholar
  13. 13.
    Freitas, A.A. and Coutinho, A. (1981) Very rapid decay of mature B lymphocytes in the spleen. J.Exp.Med. 154:994–999.PubMedCrossRefGoogle Scholar
  14. 14.
    Varela,F.J.(1987) this volume.Google Scholar
  15. 15.
    Martinez, C.-A., Marcos, M.A.R., Pereira, P. Marquez, C. Toribio, M. Cazenave, P.-A.and Coutinho, A. (1987) Turning (Ir-gene) lowresponders in high-responders by antibody manipulation of the developing immune system. J. Exp.Med. (in press)Google Scholar
  16. 16.
    Persaud, K. and Dodd, G. (1982) Analysis of discrimination mechanisms in the mammalian olfactory systems using a model nose. Nature 299:352–355PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1988

Authors and Affiliations

  • Nelson M. Vaz
    • 1
  1. 1.Departamento de Bioquímica e ImunologiaICB-UFMGBelo HorizonteBrasil

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