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Systemic Photobiological Effects of Xenobiotics

  • Conference paper
The Target Organ and the Toxic Process

Part of the book series: Archives of Toxicology ((TOXICOLOGY,volume 12))

Abstract

The conversion of 7-dehydrocholesterol into vitamin D3 and that of bilirubin into more water-soluble products, upon exposure of the body to UV-B (290–320 nm) and to visible light respectively, are two examples of systemic photo-biological effects of endogenous compounds. Vitamin D3 is essential for proper bone calcification and the photoconversion of bilirubin in the visible light therapy for neonatal jaundice results in a decrease of brain-damaging effects. That simultaneous exposure to (sun)light and a xenobiotic may also result in systemic effects is indicated by results from animal experiments.

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References

  • Beijersbergen van Henegouwen GMJ (1988) In vitro and in vivo research of phototoxic xenobiotics: structure reactivity relationships. In: Chambers PL et al (eds) Mechanisms and models in toxicology. Arch Toxicol [Suppl] 12:3–9

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Author information

Authors and Affiliations

  1. Center for Bio-Pharmaceutical Sciences, State University of Leiden, P.O. Box 9502, 2300 RA, Leiden, The Netherlands

    G. M. J. Beijersbergen van Henegouwen, R. W. Busker, H. de Vries & S. A. Schoonderwoerd

Authors
  1. G. M. J. Beijersbergen van Henegouwen
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  2. R. W. Busker
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  3. H. de Vries
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  4. S. A. Schoonderwoerd
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Editor information

Editors and Affiliations

  1. Department of Pharmacology and Therapeutics, Trinity College, University of Dublin, Dublin 2, Ireland

    Philip L. Chambers  & Claire M. Chambers  & 

  2. Institute de Biologie Moléculaire et Cellulaire du Centre National de la Recherche Scientifique and Faculté de Pharmacie, Université Louis Pasteur, 15, rue René Descartes, 67084, Strasbourg, France

    Guy Dirheimer

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© 1988 Springer-Verlag

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van Henegouwen, G.M.J.B., Busker, R.W., de Vries, H., Schoonderwoerd, S.A. (1988). Systemic Photobiological Effects of Xenobiotics. In: Chambers, P.L., Chambers, C.M., Dirheimer, G. (eds) The Target Organ and the Toxic Process. Archives of Toxicology, vol 12. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-73113-6_9

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  • DOI: https://doi.org/10.1007/978-3-642-73113-6_9

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-18512-3

  • Online ISBN: 978-3-642-73113-6

  • eBook Packages: Springer Book Archive

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