Comparison of the Effects of Sodium N-Benzyl-D-glucamine Dithiocarbamate and Ditripentat on the Toxicity, Excretion, and Tissue Distribution of Cadmium in Mice

  • V. Eybl
  • M. M. Jones
  • M. Koutenská
  • J. Koutenský
  • J. Sýkora
  • J. Drobnik
  • F. Švec
Part of the Archives of Toxicology book series (TOXICOLOGY, volume 12)

Abstract

The administration of sodium N-benzyl-D-glucamine dithiocarbamate (N-BG-DC) to rats pretreated with cadmium can effectively remove cadmium from the body (Kojima et al. 1986 a, b). The purpose of the present study was to examine the comparative influence of this chelator and that of CaDTPA (calcium — complex of diethylenetriamine pentaacetic acid) on the excretion of cadmium in mice exposed to this metal. In previous experiments CaDTPA appeared to be one of the most effective antidotes in cadmium intoxication (Eybl et al. 1984).

Keywords

Toxicity Mercury Cadmium CdCl2 Dithiocarbamate 

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References

  1. Eybl, V, Sýkora J, Koutenský J, Caisová D, Schwartz A, Mertl F (1984) Interaction of chelating agents with cadmium in mice and rats. Environ Health Perspect 54:267–273PubMedCrossRefGoogle Scholar
  2. Eybl V, Sýkora J, Drobník J, Mertl F, Švec F, Beneš M, Štamberg J, Peška J (1985) Influence of metal-complexing polymers on the retention and distribution of cadmium and mercury in mice. Plzeň Lék Sborn 49[Suppl): 169–172Google Scholar
  3. Kojima S, Kaminaka K, Kiyozumi M, Honda T (1986 a) Comparative effects of three chelating agents on distribution and excretion of cadmium in rats. Toxicol Appl. Pharmacol 83:516–524PubMedCrossRefGoogle Scholar
  4. Kojima S, Kaminaka K, Kiyozumi M, Honda T (1986 b) Effects of chelating agents on biliary and urinary excretion and tissue distribution of cadmium in rats. Toxicol Lett 34:41–46PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag 1988

Authors and Affiliations

  • V. Eybl
    • 1
  • M. M. Jones
    • 2
  • M. Koutenská
    • 3
  • J. Koutenský
    • 1
  • J. Sýkora
    • 1
  • J. Drobnik
    • 3
  • F. Švec
    • 3
  1. 1.Department of Pharmacology, Faculty of MedicineCharles UniversityPilsenCSSR
  2. 2.Department of ChemistryVanderbilt UniversityNashvilleUSA
  3. 3.Institute of Macromolecular ChemistryCS Academy of SciencesPragueCSSR

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