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The Target Organ and the Toxic Process pp 438–440Cite as

Comparison of the Effects of Sodium N-Benzyl-D-glucamine Dithiocarbamate and Ditripentat on the Toxicity, Excretion, and Tissue Distribution of Cadmium in Mice

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Part of the book series: Archives of Toxicology ((TOXICOLOGY,volume 12))

Abstract

The administration of sodium N-benzyl-D-glucamine dithiocarbamate (N-BG-DC) to rats pretreated with cadmium can effectively remove cadmium from the body (Kojima et al. 1986 a, b). The purpose of the present study was to examine the comparative influence of this chelator and that of CaDTPA (calcium — complex of diethylenetriamine pentaacetic acid) on the excretion of cadmium in mice exposed to this metal. In previous experiments CaDTPA appeared to be one of the most effective antidotes in cadmium intoxication (Eybl et al. 1984).

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References

  • Eybl, V, Sýkora J, Koutenský J, Caisová D, Schwartz A, Mertl F (1984) Interaction of chelating agents with cadmium in mice and rats. Environ Health Perspect 54:267–273

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  • Eybl V, Sýkora J, Drobník J, Mertl F, Švec F, Beneš M, Štamberg J, Peška J (1985) Influence of metal-complexing polymers on the retention and distribution of cadmium and mercury in mice. Plzeň Lék Sborn 49[Suppl): 169–172

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  • Kojima S, Kaminaka K, Kiyozumi M, Honda T (1986 a) Comparative effects of three chelating agents on distribution and excretion of cadmium in rats. Toxicol Appl. Pharmacol 83:516–524

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  • Kojima S, Kaminaka K, Kiyozumi M, Honda T (1986 b) Effects of chelating agents on biliary and urinary excretion and tissue distribution of cadmium in rats. Toxicol Lett 34:41–46

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Author information

Authors and Affiliations

  1. Department of Pharmacology, Faculty of Medicine, Charles University, Pilsen, CSSR

    V. Eybl, J. Koutenský & J. Sýkora

  2. Department of Chemistry, Vanderbilt University, Nashville, Tenn., USA

    M. M. Jones

  3. Institute of Macromolecular Chemistry, CS Academy of Sciences, Prague, CSSR

    M. Koutenská, J. Drobnik & F. Švec

Authors
  1. V. Eybl
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  2. M. M. Jones
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  3. M. Koutenská
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  4. J. Koutenský
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  5. J. Sýkora
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  6. J. Drobnik
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  7. F. Švec
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Editor information

Editors and Affiliations

  1. Department of Pharmacology and Therapeutics, Trinity College, University of Dublin, Dublin 2, Ireland

    Philip L. Chambers  & Claire M. Chambers  & 

  2. Institute de Biologie Moléculaire et Cellulaire du Centre National de la Recherche Scientifique and Faculté de Pharmacie, Université Louis Pasteur, 15, rue René Descartes, 67084, Strasbourg, France

    Guy Dirheimer

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© 1988 Springer-Verlag

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Cite this paper

Eybl, V. et al. (1988). Comparison of the Effects of Sodium N-Benzyl-D-glucamine Dithiocarbamate and Ditripentat on the Toxicity, Excretion, and Tissue Distribution of Cadmium in Mice. In: Chambers, P.L., Chambers, C.M., Dirheimer, G. (eds) The Target Organ and the Toxic Process. Archives of Toxicology, vol 12. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-73113-6_85

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  • DOI: https://doi.org/10.1007/978-3-642-73113-6_85

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-18512-3

  • Online ISBN: 978-3-642-73113-6

  • eBook Packages: Springer Book Archive

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