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DNA Damage Caused by Laser Light Activated Hematoporphyrin Derivatives in Isolated Nuclei of Human Melanoma Cells

  • M. Artuc
  • M. Ramshad
  • C. Reinhold
  • H. Kappus
Part of the Archives of Toxicology book series (TOXICOLOGY, volume 12)

Abstract

Hematoporphyrin derivatives (HPDs) are used in the chemotherapy of various tumors. They are a mixture of dimers and oligomers of hematoporphyrin linked by ether and ester bonds (for reviews see Kessel 1986a; Pottier and Truscott 1986). They accumulate in tumor cells and are cytotoxic after photosensitization with laser light. Reactive oxygen species formed during irradiation of HPDs are most likely responsible for the cytotoxicity observed (Keene et al. 1986; van Steveninck et al. 1986; Buettner and Hall 1987). However, the cellular target for these reactive oxygen species has not yet been identified. Critical oxidizable sites of mitochondria or the outer cellular membrane have been related to laser-activated HPD toxicity (Atlante et al. 1986; Kessel 1986b; Moan and Vistnes 1986; Salet 1986).

Keywords

Reactive Oxygen Species Melanoma Cell Singlet Oxygen Human Malignant Melanoma Cell Line Hematoporphyrin Derivative 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag 1988

Authors and Affiliations

  • M. Artuc
    • 1
  • M. Ramshad
    • 2
  • C. Reinhold
    • 1
  • H. Kappus
    • 1
  1. 1.Free University of BerlinBerlin 65Germany
  2. 2.Free University of BerlinBerlin 65Germany

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