Comparative Toxicity of Three Quinoxaline-di-N-dioxide Feed Additives in Young Pigs

  • A. J. Baars
  • E. J. van der Molen
  • T. J. Spierenburg
  • G. J. de Graaf
  • M. J. A. Nabuurs
  • L. P. Jager
Conference paper
Part of the Archives of Toxicology book series (TOXICOLOGY, volume 12)

Abstract

The quinoxaline-di-N-dioxide derived feed additives carbadox, olaquindox, and cyadox are widely used as growth promoters in modern pig husbandry (Aumaitre and Raynaud 1978; Bronsch et al. 1976; Herzig et al. 1984). Carbadox and olaquindox have also been demonstrated to protect against several enteric pathogens such as Treponema hyodysenteriae, an anaerobic spirochete involved in the pathogenesis of swine dysentery (Blobel and Schliesser 1979). In earlier studies from this institute it was demonstrated that doses of carbadox in feed of less than twice the recommended one of 50 ppm induced toxic side-effects, causing specific adrenal lesions (Van der Molen et al. 1985), and it was suggested that carbadox interacts with the biosynthesis of aldosterone (Van der Molen et al. 1986a, b).

Keywords

Toxicity Aldosterone Dium Mineralocorticoid Quinoxaline 

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References

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Copyright information

© Springer-Verlag 1988

Authors and Affiliations

  • A. J. Baars
    • 1
  • E. J. van der Molen
    • 1
  • T. J. Spierenburg
    • 1
  • G. J. de Graaf
    • 1
  • M. J. A. Nabuurs
    • 1
  • L. P. Jager
    • 1
  1. 1.Central Veterinary InstituteLelystadThe Netherlands

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