Comparative Toxicity of Three Quinoxaline-di-N-dioxide Feed Additives in Young Pigs
The quinoxaline-di-N-dioxide derived feed additives carbadox, olaquindox, and cyadox are widely used as growth promoters in modern pig husbandry (Aumaitre and Raynaud 1978; Bronsch et al. 1976; Herzig et al. 1984). Carbadox and olaquindox have also been demonstrated to protect against several enteric pathogens such as Treponema hyodysenteriae, an anaerobic spirochete involved in the pathogenesis of swine dysentery (Blobel and Schliesser 1979). In earlier studies from this institute it was demonstrated that doses of carbadox in feed of less than twice the recommended one of 50 ppm induced toxic side-effects, causing specific adrenal lesions (Van der Molen et al. 1985), and it was suggested that carbadox interacts with the biosynthesis of aldosterone (Van der Molen et al. 1986a, b).
KeywordsFeed Additive Aldosterone Production Adrenal Zona Glomerulosa Hydropic Change Standard Atomic Absorption
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