Comparative Toxicity of Three Quinoxaline-di-N-dioxide Feed Additives in Young Pigs
The quinoxaline-di-N-dioxide derived feed additives carbadox, olaquindox, and cyadox are widely used as growth promoters in modern pig husbandry (Aumaitre and Raynaud 1978; Bronsch et al. 1976; Herzig et al. 1984). Carbadox and olaquindox have also been demonstrated to protect against several enteric pathogens such as Treponema hyodysenteriae, an anaerobic spirochete involved in the pathogenesis of swine dysentery (Blobel and Schliesser 1979). In earlier studies from this institute it was demonstrated that doses of carbadox in feed of less than twice the recommended one of 50 ppm induced toxic side-effects, causing specific adrenal lesions (Van der Molen et al. 1985), and it was suggested that carbadox interacts with the biosynthesis of aldosterone (Van der Molen et al. 1986a, b).
KeywordsToxicity Aldosterone Dium Mineralocorticoid Quinoxaline
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- Blobel H, Schliesser T (1979) Handbuch der bacteriellen Infektionen bei Tieren, vol. 1. Fischer, Jena, pp 506–509Google Scholar
- Ferguson PR, James PS, Paterson JYF, Saunders JC, Smith MW (1979) Aldosterone induced changes in colonic sodium transport occurring naturally during development in the neonatal pig. J Physiol (Lond) 292:495–504Google Scholar
- Herzig I, Toulova M, Pisarikova B (1984) Effect of the growth promoter cyadox on the digestibility of nutrients in the feed for fattening pigs. Biol Chem Zivocisne Vyroby Vet 20:235–239Google Scholar
- Hewick DS (1982) Reductive metabolism of nitrogen-containing functional groups. In: Jakoby WB, Bend JR, Caldwell J (eds) Metabolic basis of detoxification. Academic, New York, pp 151–170Google Scholar
- Nelson DH (1980) Aldosterone and the mineralocorticoids. In: Nelson DH, The adrenal cortex: physiological function and disease. Saunders, Philadelphia, Chapt 7, pp 89–101Google Scholar
- Van der Molen EJ, Nabuurs MJA, Jager LP (1985) Pathological and clinical changes related to toxicity of carbadox in weaned pigs. J Vet Med [A] 32:540–550Google Scholar