Organic Solvents Affect Rat Synaptosome Membrane Acetylcholinesterase and Adenosine Triphosphatase In Vitro
The common toxic effect of organic solvents is their CNS depression. The mechanism of this anesthetic action is a matter of controversy, but recent investigations suggest that anesthetic agents can act nonspecifically with large hydrophobic regions of membrane proteins rather than with membrane bilayer. Changes in the lipid composition of nerve cell membrane have not been shown to happen at clinical concentrations of anesthetic agents (Franks and Lieb 1982).
KeywordsBenzene Toluene Hydrocarbon Adenosine Chlorinate
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