Quantitative Morphology of Hepatocyte Nuclei in the Comparative Studies of Di(2-ethylhexyl)phthalate Effects
Di(2-ethylhexyl)phthalate (DEHP) is a widespread environmental contaminant with potential toxic and carcionogenic effects. Although the biological action of DEHP has been a subject of intense study, the question of whether or not it poses a substantial human hazard still remains unanswered (Reddy and Lalwai 1983). In this regard species- and dose-related differences in responses to DEHP action appear important (Albro et al. 1982). So far the carcinogenicity of DEHP has only been demonstrated in rats and mice by giving very high doses (NTP 1982). The low order of acute toxicity and the lack of consistent pathological findings at low doses delineate other aspects of DEHP action. Still little is known about subtle DEHP effects that may be induced by the level of the expected environmental exposure (NTP 1981). In an attempt to describe subtle changes and recognize species-related differences, we applied image analysis to hepatocyte nuclei of rats and hamsters treated by single doses of DEHP.
KeywordsToxicity Dioxide Macromolecule Phthalate Toxicology
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