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Photomutagenicity Induced by Psoralens: Modulation of the Photomutagenic Response in Eukaryotes

  • Conference paper
The Target Organ and the Toxic Process

Part of the book series: Archives of Toxicology ((TOXICOLOGY,volume 12))

Abstract

Photoreactive furocoumarins (psoralens), such as 8-methoxypsoralen (8-MOP) and 5-methoxypsoralen (5-MOP), present in many plant extracts (Scott et al. 1976), are used in the photochemotherapeutic treatment (PUVA) of psoriasis and other skin disorders (Parrish et al. 1982) and in cosmetology (Suzuki et al. 1979). Thus, the evaluation of photomutagenic effects of psoralens is an important task with respect to long-term effects (Averbeck 1984; Ben-Hur and Song 1984; Scott et al. 1976) which may arise in humans (Stern 1984).

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Authors and Affiliations

  1. Institut Curie - Biologie, 26 rue d’Ulm, 75231, Paris cedex 05, France

    D. Averbeck

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  1. D. Averbeck
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  1. Department of Pharmacology and Therapeutics, Trinity College, University of Dublin, Dublin 2, Ireland

    Philip L. Chambers  & Claire M. Chambers  & 

  2. Institute de Biologie Moléculaire et Cellulaire du Centre National de la Recherche Scientifique and Faculté de Pharmacie, Université Louis Pasteur, 15, rue René Descartes, 67084, Strasbourg, France

    Guy Dirheimer

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© 1988 Springer-Verlag

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Averbeck, D. (1988). Photomutagenicity Induced by Psoralens: Modulation of the Photomutagenic Response in Eukaryotes. In: Chambers, P.L., Chambers, C.M., Dirheimer, G. (eds) The Target Organ and the Toxic Process. Archives of Toxicology, vol 12. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-73113-6_5

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  • DOI: https://doi.org/10.1007/978-3-642-73113-6_5

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-18512-3

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