Di-(2-ethylhexyl) Adipate and Peroxisome Proliferation: Identification of Proximate Peroxisomal Proliferator In Vivo and In Vitro

  • Y. Keith
  • M. C. Cornu
  • C. R. Elcombe
  • J. C. Lhuguenot
Conference paper
Part of the Archives of Toxicology book series (TOXICOLOGY, volume 12)

Abstract

Di-(2-ethylhexyl) adipate (DEHA), a plasticizer used in the manufacture of polyvinyl chloride plastics products, has been shown to be a hepatic peroxisome proliferator for rodents (Moody et al. 1978, 1982). Long-term feeding experiments performed by the National Toxicology Program (NTP, 1982) found DEHA to be carcinogenic in female B6C3F1 mice and probably carcinogenic in male B6C3F1 mice. Unter certain conditions, DEHA may migrate from the plastic into lipophilic surroundings; hence a potential risk for human exists.

Keywords

Cholesterol Hydrolysis Peroxi Albumin Petrol 

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References

  1. Albro PW (1975) The metabolism of 2-ethylhexanol in rats. Xenobiotica 5/10:625–636PubMedCrossRefGoogle Scholar
  2. Bronfman M, Inestrosa NC, Leighton F (1970) Fatty acid oxidation by human liver peroxisomes. Biochem Biophys Res Commun 88:1030–1036CrossRefGoogle Scholar
  3. Komarov NV, Kotlyarevskii IL (1959) Synthesis of acid and mixed esters of adipic acid. NV, Zhur Priklad Khim 32:2826–2828Google Scholar
  4. Lowry OH, Rosebrough NJ, Farr AL, Randall RJ (1951) Protein measurements. J Biol Chem 193:265–275PubMedGoogle Scholar
  5. Mitchell AM, Bridges JW, Elcombe CR (1984) Factors influencing peroxisome proliferation in cultured rat hepatocytes. Anch Toxicol 55:239–246CrossRefGoogle Scholar
  6. Mitchell AM, Lhuguenot JC, Bridges JW, Elcombe CR (1985) Identification of the proximate peroxisome proliferator(s) derived from di-(2-ethylhexyl) phthalate. Toxicol Appl Pharmacol 79:23–32CrossRefGoogle Scholar
  7. Moody DE, Reddy JK (1978) Hepatic peroxisome (microbody) proliferation in rats fed plasticizers and related compounds. Toxicol Pharmacol 45:497–504Google Scholar
  8. Moody DE; Reddy JK (1982) Serum triglyceride and cholesterol contents in male rats receiving diets containing plasticizers and analogues of the ester 2-ethylhexanol. Toxicology Letters 10:379–383PubMedCrossRefGoogle Scholar
  9. National Toxicology Program (1982) Carcinogenesis bioassay of di(2-ethylhexyl) adipate (CAS n° 103–23–1). NTP Tech Rep Series n°212Google Scholar
  10. Osumi T, Hashimoto T (1978) Enhancement of Falty acyl-CoA oxidising activity in rat liver peroxisome by di-(2-ethylhexyl)phtalate. T Biochem 83:1361–1365Google Scholar
  11. Takahashi T, Tamaka A, Yamaha T (1981) Elimination, distribution and metabolism of di- (2-ethylhexyl) adipate (DEHA) in rats. Toxicol. 22:222–223Google Scholar

Copyright information

© Springer-Verlag 1988

Authors and Affiliations

  • Y. Keith
    • 1
  • M. C. Cornu
    • 1
  • C. R. Elcombe
    • 2
  • J. C. Lhuguenot
    • 1
  1. 1.Département de Biochimie et Toxicologie Alimentaires, ENS.BANACampus UniversitaireDijonFrance
  2. 2.Central Toxicology LaboratoryImperial Chemical IndustriesCheshireEngland

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